Core 3: Computational (290-307)

核心 3：计算 (290-307)

• 批准号: 8078168
• 负责人: RANDALL CHARLES O'REILLY
• 金额: $ 23.88万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-03 至 2013-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8078168
• 关键词: Accounting; Address; Behavioral; Brain; Characteristics; Child Development; Computer Analysis; Computer Simulation; Data; Development; Disease; Emotional; Emotions; Ethics; Faculty; Goals; Human Resources; Intervention; Investigation; Learning; Lesion; Link; Mental disorders; Methods; Modeling; Neuroanatomy; Neurobiology; Postdoctoral Fellow; Process; System; Techniques; Testing; Thinking; Training; Work; cognitive control; computer infrastructure; design; executive function; insight; member; neuroimaging; neuropsychological; psychologic; research study

The computational modeling core is designed to support the development of biologically plausible computational models across the range of projects proposed in the center. Various existing models have been developed for the experimental tasks employed across all of the proposed projects. This includes models of cognitive control (Project 1), learning (Project 2), emotion (Project 3), dompainergic infulences on executive funciton (Project 4) and child development (Project 5). Because these models are biologically inspired they consider both neurobiological and psychological constraints on processing. The development of computational models provides an important way of synthesizing experimental results in a mechanistic fashion, and generating predictions for further experimental studies. These models will be used in parallel with empirical investigations so that theycan inform each other. Because of these characteristics, the computational core explicitly addresses a center goal of linking levels of analysis (computational, psychological, and neurobiological) in our understanding of executive function. The personnel associated with the computational core will provide both the faculty and post-doctoral expertise with regards to the creation, implementation and evaulation of comptuational models for all projects within the center. In addition, it will provide the computational infrastructure for those investigations as well as training materials and training opportunity for center members. Computational models of executive function can provide insights into psychiatric disorders in numerous ways. For example, models can be "lesioned" or altered in ways that are impossible to do experimentally for either ethical or practical reasons. As such, they can provide insights into the mechanisms that support disordered thoughts or emotional processes. Furthermore, they may provide insights into mechanisms or interventions that might be effective in overcoming such disorders. This is especially true of the models proposed for this center, which are explicitly linked to the neuroanatomy and functioning of brain systems as well as the psychological processes that support executive function.

计算建模核心旨在支持生物学上合理的发展 在该中心提出的项目范围内的计算模型。现有的各种模型 为所有拟议项目中采用的实验任务而开发。这包括 认知控制（项目1），学习（项目2），情绪（项目3），domainergic infulences对 执行功能（项目4）和儿童发展（项目5）。因为这些模型在生物学上 受到启发，他们考虑了神经生物学和心理学对处理的限制。发展 的计算模型提供了一个重要的途径，综合实验结果，在一个机械 时尚，并为进一步的实验研究产生预测。这些模型将并行使用 with empirical经验investigations调查so that theycan inform通知each每other.由于这些特点， 计算核心明确地解决了连接分析级别的中心目标（计算， 心理学和神经生物学）在我们对执行功能的理解中。 与计算核心相关的人员将提供教师和博士后 在所有项目的计算模型的创建、实施和评估方面的专业知识 在中心。此外，它还将为这些调查提供计算基础设施 作为中心成员的培训材料和培训机会。 执行功能的计算模型可以提供对许多精神疾病的见解， 的方式例如，模型可以被“损伤”或以实验上不可能做到的方式改变。 无论是道德还是现实原因。因此，它们可以提供对支持 混乱的思想或情感过程。此外，它们还可以提供有关机制的见解， 可能有效克服这些障碍的干预措施。这一点在模型中尤为明显 为这个中心提出，这是明确联系到神经解剖学和大脑系统的功能， 以及支持执行功能的心理过程。