GENETICS OF INHIBITOR DEVELOPMENT IN HEMOPHILIA

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The project is designed to test the hypothesis that genetic causes contribute significantly to the risk of inhibitor development in hemophilic patients treated with factor VIII concentrates. The study entails the collection of DNA and clinical data from 200 sibling pairs of severe hemophilia A and genetic links to inhibitor development will be analyzed through a candidate gene and genome wide scanning approaches.