GENETICS OF INHIBITOR DEVELOPMENT IN HEMOPHILIA

血友病抑制剂发展的遗传学

• 批准号: 7375064
• 负责人: JOAN COX GILL
• 金额: $ 0.13万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375064
• 关键词: GENETICS; INHIBITOR; DEVELOPMENT; HEMOPHILIA

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The project is designed to test the hypothesis that genetic causes contribute significantly to the risk of inhibitor development in hemophilic patients treated with factor VIII concentrates. The study entails the collection of DNA and clinical data from 200 sibling pairs of severe hemophilia A and genetic links to inhibitor development will be analyzed through a candidate gene and genome wide scanning approaches.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。该项目旨在检验以下假设：遗传原因对接受因子VIII浓缩物治疗的血友病患者中抑制物形成的风险有显著影响。该研究需要从200对严重血友病A的兄弟姐妹中收集DNA和临床数据，并将通过候选基因和全基因组扫描方法分析抑制剂发展的遗传联系。