THE SECOND MULTICENTER HEMOPHILIA COHORT STUDY (MHCS-II)

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。第二项多中心血友病队列研究旨在评估和前瞻性随访4500名暴露于丙型肝炎的血友病患者;约1/3也将感染HIV。主要目的是量化肝脏失代偿、肝细胞癌和NH淋巴瘤的发生率，并评估这些疾病因果途径上的候选临床、遗传、神经学、血清学和免疫学标志物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Second Multicenter Hemophilia Cohort Study aims to evaluate and prospectively follow 4500 persons with hemophilia exposed to hepatitis C; about 1/3 will also be HIV-infected. Primary objectives are to quantify rates of liver decompensation, hepatocellular carcinoma and NH lymphoma and to evaluate candidate clinical, genetic, neurologic, serologic and immunologic markers on the causal pathway for these conditions.