Time-based high-content screening

基于时间的高内涵筛选

• 批准号: BB/E012574/1
• 负责人: Rachel Errington
• 金额: $ 30.51万
• 依托单位: CARDIFF UNIVERSITY
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FE012574%2F1
• 关键词: Time; based; content; screening

Microscopy and cellular imaging has hitherto been amenable to small-scale experimental samples. New approaches to cell-based analysis are required to meet the demanding needs of cell-biology, genetics and experimental therapeutics. At the core is the need to convert images into numbers, this is a significant challenge which would greatly enhance the ability of the biologist to effectively interrogate and interpret complex data. To achieve large-scale imaging experiments we need to address critical issues of data bottlenecks. High-throughput screening instrumentation has been available in the commercial sector for the last five years, therefore the objective is to bring these capabilities to academia. Such equipment not only greatly augments research capacity but provides new opportunities taking a systems approach to cell-biology.

迄今为止，显微镜和细胞成像适用于小规模实验样本。需要新的细胞分析方法来满足细胞生物学、遗传学和实验治疗学的苛刻需求。核心是将图像转换为数字，这是一个重大挑战，它将大大增强生物学家有效询问和解释复杂数据的能力。为了实现大规模成像实验，我们需要解决数据瓶颈的关键问题。高通量筛选仪器在过去五年中已在商业领域投入使用，因此我们的目标是将这些功能引入学术界。此类设备不仅极大地增强了研究能力，而且提供了采用系统方法研究细胞生物学的新机会。

项目成果

Cell lineage visualisation

• DOI: 10.1111/cgf.12614
• 发表时间: 2015-06-01
• 期刊: COMPUTER GRAPHICS FORUM
• 影响因子: 2.5
• 作者: Pretorius, A. J.;Khan, I. A.;Errington, R. J.
• 通讯作者: Errington, R. J.

Impact of overexpression of metallothionein-1 on cell cycle progression and zinc toxicity.

金属硫蛋白-1 过度表达对细胞周期进程和锌毒性的影响。

• DOI: 10.1152/ajpcell.00342.2008
• 发表时间: 2008
• 期刊: American journal of physiology. Cell physiology
• 作者: Smith PJ

A Survey of Visualization for Live Cell Imaging

• DOI: 10.1111/cgf.12784
• 发表时间: 2017-01-01
• 期刊: COMPUTER GRAPHICS FORUM
• 影响因子: 2.5
• 作者: Pretorius, A. J.;Khan, I. A.;Errington, R. J.
• 通讯作者: Errington, R. J.

Cytomics and cellular informatics--coping with asymmetry and heterogeneity in biological systems.

• DOI: 10.1016/j.drudis.2008.11.012
• 发表时间: 2009-03
• 期刊: Drug discovery today
• 影响因子: 7.4
• 作者: Paul J. Smith;I. Khan;R. Errington