ISOFLAVONES IN PROSTATE CANCER UNDERGOING ANDROGEN DEPRIVATION THERAPY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本建议的总体目标是研究sy蛋白对正在接受药物阉割或已经接受手术阉割的前列腺癌患者的认知、生活质量和潮热的影响。历史上，根治性前列腺切除术和/或放射治疗一直是局部局限性前列腺癌患者的主要治疗方法。然而，对于转移性前列腺癌患者或复发患者（通过PSA升高检测），雄激素剥夺疗法（ADT）经常被采用。ADT最常见的模式是使用GnRH激动剂导致中枢性性腺功能减退（少数进行睾丸切除术）。在性腺功能减退的男性中，一些低睾酮血症的并发症已经被描述过。这些包括瘦体质量（LBM）下降、肌肉力量、骨质疏松、生活质量（QOL）下降和性功能障碍。性腺功能减退的另一个并发症是潮热。这种并发症在接受ADT的男性前列腺癌患者中发生率最高（80-90%的患者）。绝经后妇女的研究表明，在雌激素替代疗法后，记忆任务的表现有所改善。由于雌激素治疗的潜在风险，重点正在转移到植物雌激素（异黄酮）。研究前列腺癌患者证明了评估异黄酮对男性认知影响的最佳模型，同时提供了所需的生活质量改善。此外，它还可以改善潮热。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this proposal is to investigate the effect of sy protein on cognition, quality of life and hot flashes in men with prostate cancer who are currently undergoing medical castration or have undergone surgical castration. Historically, radical prostatectomy and/or radiation therapy has been the mainstay of treatment in patients with locally confined PCa. However, for patients with metastatic PCa or those with a recurrence (detected by a rising PSA), androgen deprivation therapy (ADT) is frequently employed. The most common mode of ADT is the use of GnRH agonists which result in central hypogonadism (orchiectomy is performed in minority). Several complications of hypotestosteronemia have been described in men with hypogonadism. These include decline in lean body mass (LBM), muscle strength, osteoporosis, decrease in quality of life (QOL) and sexual dysfunction. Another complication of hypogonadism is hot flashes. This complication is seen with the highest frequency in men with PCa undergoing ADT (80-90% of the patients). Studies of postmenopausal women indicate that performance on tasks of memory improves following estrogen replacement therapy. Due to the potential risks involved with estrogen therapy, focus is being shifted to plant estrogens (isoflavones). Studying men with PCa proves the best model to evaluate the effects of isoflavones on cognition in men, while providing needed improvement in QOL. Furthermore, it may also result in an improvement in hot flashes.