Selenium, Isoflavones, Androgen Metabolism and Prostate Cancer Risk Reduction

描述(申请人提供)：本研究的目的是阐明硒(Se)和植物雌激素相互作用降低前列腺癌风险的生化和分子机制。这一目标非常重要；如果成功，这项研究可能会提供有关硒和异黄酮类化合物在前列腺癌中作用的有用信息。申请人对以前的批评作出了非常积极的回应，并提供了新的初步数据。这一假设是重要的，方法也是充分的。额外的优势是申请者与学生合作进行研究培训的长期历史，这符合R15拨款机制的目的。有人担心这项过于雄心勃勃的研究在短时间内使用了大量的小鼠，而且预算有限。然而，拟议的研究被认为具有潜在的重要意义，成功的可能性很高。

DESCRIPTION (provided by applicant): The purpose of this study is to elucidate the biochemical and molecular mechanisms by which the interaction of selenium (Se) and phytoestrogens reduces the risk for prostate cancer. The objective is highly significant; if successful, the study could provide useful information on the role of Se and isoflavonoids in prostate cancer. The applicant was very responsive to the previous critiques and has provided with new preliminary data. The hypothesis is significant and the approach is adequate. Additional strength is the applicant's long history of working with students for research training which fulfills the purpose of the R15 grant mechanism. There are some concerns about the overly ambitious study with large number of mice in a short time span and with a limited budget. Nevertheless, the proposed research is seen as potentially important with a high probability for it being successful.