METABOLIC EFFECTS OF BRAIN RADIATION IN CHILDREN

脑辐射对儿童代谢的影响

• 批准号: 7378851
• 负责人: ALENA HORSKA
• 金额: $ 1.29万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378851
• 关键词: METABOLIC; EFFECTS; BRAIN; RADIATION; CHILDREN

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Aggressive radiation therapy (RT) has contributed positively to long term disease-free survival from childhood cancer. Despite its therapeutic benefit, RT has been associated with a spectrum of acute, early-delayed, and late-delayed toxicities to the central nervous system. As a consequence, pediatric patients treated with brain radiation often develop neurological and neurocognitive deficits manifesting as behavioral or learning disabilities. It is unclear whether the neurocognitive deficits are due mainly to damage to the subcortical structures or if cortical areas are also involved. We plan using non-invasive methods based on magnetic resonance (MR - magnetic resonance spectroscopy, volumetric MRI, and diffusion tensor imaging) to determine a) how brain function, as measured by MR techniques, can be correlated with total radiation dose delivered to the brain and b) whether changes in measured parameters (metabolite concentration, lobar tissue volumes, and water diffusion characteristics) can be used as surrogate markers to predict the neuropsychological outcome from RT. We plan to perform a longitudinal MR study with a 30 months follow-up to assess changes in brain metabolism (using proton MR spectroscopy), loss of brain tissue (using volumetric MRI), and damage to tissue microstructure (using diffusion tensor imaging). Concurrent neuropsychological assessments will be performed to evaluate the neuropsychological status. Linear mixed effects (LME) regression analyses will be applied to examine the effect of radiation doses on regional brain metabolite levels, changes in lobar brain volumes and diffusion properties of water in the brain tissue and to evaluate the relationship between neuropsychological test scores and parameters measured by the proposed MR methods.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。积极的放射治疗（RT）对儿童癌症的长期无病生存有积极的贡献。尽管它具有治疗益处，但RT与一系列急性、早发性和晚发性中枢神经系统毒性有关。因此，接受脑辐射治疗的儿科患者往往会出现神经和神经认知缺陷，表现为行为或学习障碍。目前尚不清楚神经认知缺陷主要是由于皮层下结构的损伤还是皮层区域也参与其中。我们计划使用基于磁共振（MR -磁共振波谱，体积MRI和弥散张量成像）的非侵入性方法来确定a)通过磁共振技术测量的脑功能如何与传递到大脑的总辐射剂量相关，b)测量参数(代谢物浓度，叶状组织体积，和水扩散特征)可以作为替代标记来预测rt的神经心理结果。我们计划进行一项为期30个月的纵向磁共振研究，以评估脑代谢的变化（使用质子磁共振光谱），脑组织的损失（使用体积磁共振成像）和组织微观结构的损伤（使用扩散张量成像）。同时进行神经心理评估以评估神经心理状态。线性混合效应（LME）回归分析将用于检查辐射剂量对区域脑代谢物水平、脑叶体积变化和脑组织中水扩散特性的影响，并评估神经心理学测试分数与拟议MR方法测量的参数之间的关系。