Transmission Electron Microscope

这是购买最先进的透射电子显微镜（TEM）的建议。透射电镜是生物学研究的一项重要技术，因为它是目前在分子水平上非常详细地观察细胞和亚细胞结构的最佳方法。由于这些机器昂贵且维护耗时，我们建议将显微镜共享给诺里奇毗邻的3个合作机构：约翰英纳斯中心、食品研究所和东安格利亚大学生物科学系。所提出的显微镜将具有进行亚细胞结构三维重建的能力，这将克服生物电子显微镜最重要的局限性之一/通常只能产生生物结构的二维图像。该设备将用于培训许多学生和其他科学家使用瞬变电磁法，这一点很重要，因为越来越少的生物学家正在学习这些技能。从约翰英纳斯大学的基础植物细胞生物学和微生物学，到IFR的食品科学和东安格利亚大学的生物医学研究，它将为合作机构的广泛研究提供重要组成部分。新机器将取代三个地点非常旧的机器，这些机器已达到使用寿命，很快将无法维护。

This is a proposal to purchase a state-of-the-art transmission electron microscope (TEM). TEM is an essential technique for biological research, because it is currently the best way of visualising cellular and sub-cellular structures in great detail / in favourable cases at the molecular level. Because these machines are expensive and time-consuming to maintain, we propose to share the microscope between 3 partner institutions which are adjacent to each other in Norwich: the John Innes Centre, the Institute of Food Research and the Biological Sciences Department of the University of East Anglia. The proposed microscope would have the capability of carrying out 3D reconstructions of sub-cellular structures, which would overcome one of the most significant limitations of biological electron microscopy / that only a 2D picture of the biological structures is nomally produced. The equipment will be used to train many students and other scientists in the use of TEM, which is important as fewer and fewer biologists are learning these skills. It will provide a crucial part of a wide range of research across the partner institutions, from basic plant cell biology and microbiology at John Innes to food science at IFR and biomedical research at the University of East Anglia. The new machine will replace very old machines at the three sites which have reached the end of their useful life and will soon be impossible to maintain.