WEIGHT LOSS IN OVERWEIGHT PATIENTS WITH CORONARY HEART DISEASE + TYPEII DIABETES

患有冠心病、II 型糖尿病的超重患者的体重减轻

• 批准号: 7378598
• 负责人: PHILIP A. ADES
• 金额: $ 7.5万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-09 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378598
• 关键词: adipose tissue; exercise; fats; heart; macrophage; proteins; rehabilitation; tumor necrosis factor alpha; weight loss

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The United States is currently experiencing an epidemic of obesity and type II diabetes. Over half of the general population is classified as overweight. In that being overweight is associated with a number of cardiac risk factors such as high cholesterol, high blood pressure and diabetes, overweight people are much more likely to develop coronary heart disease (CHD) than average-weight people. In fact 75-88% of people with recently diagnosed CHD are overweight and over 20% of these individuals have Type II diabetes. Cardiac Rehabilitation exercise programs for people with CHD have not been very effective in helping people lose weight through exercise-alone. We propose to study the effectiveness of: 1. A behaviorally-based weight loss program characterized by a daily calorie-intake goal and substantial behavioral and social support to attain dietary goals, and 2. An exercise program to assist with the weight loss intervention. The exercise program is characterized by almost daily exercise at the Cardiac Rehabilitation/ GCRC Exercise Testing and Training facility along with home-based walking. Outcome measures will include, body weight, fat mass and abdominal fat by CT scanning, measures of blood lipids, C-reactive protein, measures of clotting, vasodilatory capacity, glucose tolerance, echocardiographic cardiac function and an abdominal fat biopsy. Adipose tissue will be analyzed in Dr. Pratley's laboratory for gene expression levels of leptin, adiponectin, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha ), macrophage chemotactic protein (MCP), macrophage inhibitory protein (MIP) and plasminogen activator-inhibitor-1 (PAI-1); all associated with adipose tissue, inflammation and thrombosis.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。美国目前正在经历肥胖和II型糖尿病的流行。超过一半的总人口被归类为超重。由于超重与许多心脏病风险因素有关，如高胆固醇、高血压和糖尿病，超重的人比体重正常的人更容易患冠心病（CHD）。事实上，75-88%的最近诊断为CHD的人超重，其中超过20%的人患有II型糖尿病。冠心病患者的心脏康复锻炼计划在帮助人们通过单独锻炼减肥方面并不是很有效。我们建议研究的有效性：1。一个基于行为的减肥计划，其特征是每日卡路里摄入量目标和大量的行为和社会支持，以实现饮食目标，和2。一个运动计划，以协助减肥干预。运动计划的特点是几乎每天在心脏康复/ GCRC运动测试和训练机构进行运动，沿着在家步行。结果测量将包括体重、脂肪量和腹部脂肪（通过CT扫描）、血脂测量、C-反应蛋白、凝血测量、血管舒张能力、葡萄糖耐量、超声心动图心脏功能和腹部脂肪活检。将在Pratley博士的实验室分析脂肪组织的瘦素、脂联素、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、巨噬细胞趋化蛋白（MCP）、巨噬细胞抑制蛋白（MIP）和纤溶酶原激活物-抑制剂-1（派-1）的基因表达水平;所有这些都与脂肪组织、炎症和血栓形成相关。