METHODS OF WEIGHT LOSS IN OVERWEIGHT PATIENTS WITH CORONARY HEART DISEASE

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to study the effectiveness of a low calorie diet and two different types of exercise on weight control in overweight patients with Coronary Heart Disease (CHD). We will also closely measure the benefits of weight loss as it relates to measures that predict risk of further cardiac problems. These include cholesterol profiles, measures of glucose metabolism, body fat distribution and measures of blood clotting. Methods of weight loss and subsequent benefits in people with CHD have not been very well studied. We propose to study the effectiveness of: 1. A behaviorally-based weight loss program characterized by a daily calorie-intake goal and substantial behavioral and social support to attain dietary goals, and 2. Either of 2 types of supplementary exercise programs to assist with the weight loss intervention. These are characterized by variable amounts of exercise at our Cardiac Rehabilitation facility on the UVM campus, and home-walking. Strong evidence supports that exercise and improved coronary risk factors (cholesterol, blood pressure etc.) can significantly contribute to a reduction of fatal and non-fatal coronary events, an improved quality of life, and an increased life expectancy for people with coronary heart disease. In this study we will focus on the value of weight loss and exercise on decreasing future risk of heart problems.