METHODS OF WEIGHT LOSS IN OVERWEIGHT PATIENTS WITH CORONARY HEART DISEASE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的目的是研究低热量饮食和两种不同类型的运动对超重冠心病（CHD）患者体重控制的有效性。我们还将密切衡量减肥的好处，因为它与预测进一步心脏问题的风险有关。这些指标包括胆固醇谱、葡萄糖代谢测量、体脂分布和血液凝固测量。对冠心病患者的减肥方法和随后的益处还没有很好的研究。我们建议研究的有效性：1。一种以行为为基础的减肥计划，其特点是每日卡路里摄入目标和实现饮食目标的大量行为和社会支持。辅助减肥干预的两种补充性运动计划之一。这些活动的特点是在弗吉尼亚大学校园内的心脏康复中心进行不同程度的锻炼，以及在家散步。强有力的证据支持，运动和改善冠状动脉危险因素（胆固醇、血压等）可以显著有助于减少致命性和非致命性冠状动脉事件，改善生活质量，延长冠心病患者的预期寿命。在这项研究中，我们将重点关注减肥和锻炼在降低未来患心脏病风险方面的价值。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to study the effectiveness of a low calorie diet and two different types of exercise on weight control in overweight patients with Coronary Heart Disease (CHD). We will also closely measure the benefits of weight loss as it relates to measures that predict risk of further cardiac problems. These include cholesterol profiles, measures of glucose metabolism, body fat distribution and measures of blood clotting. Methods of weight loss and subsequent benefits in people with CHD have not been very well studied. We propose to study the effectiveness of: 1. A behaviorally-based weight loss program characterized by a daily calorie-intake goal and substantial behavioral and social support to attain dietary goals, and 2. Either of 2 types of supplementary exercise programs to assist with the weight loss intervention. These are characterized by variable amounts of exercise at our Cardiac Rehabilitation facility on the UVM campus, and home-walking. Strong evidence supports that exercise and improved coronary risk factors (cholesterol, blood pressure etc.) can significantly contribute to a reduction of fatal and non-fatal coronary events, an improved quality of life, and an increased life expectancy for people with coronary heart disease. In this study we will focus on the value of weight loss and exercise on decreasing future risk of heart problems.