METHODS OF WEIGHT LOSS IN OVERWEIGHT PATIENTS WITH CORONARY HEART DISEASE

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 本研究的目的是研究低热量饮食和两种不同类型的运动对超重冠心病患者体重控制的有效性。 我们还将密切衡量减肥的好处，因为它与预测进一步心脏问题风险的措施有关。 这些包括胆固醇分布、葡萄糖代谢的测量、身体脂肪分布和血液凝固的测量。 冠心病患者的减肥方法和随后的益处尚未得到很好的研究。 我们建议研究以下措施的成效： 1. 一个基于行为的减肥计划，其特征是每日卡路里摄入量目标和大量的行为和社会支持，以实现饮食目标，以及 2. 2种辅助运动计划中的任何一种，以协助减肥干预。 这些特点是在我们的心脏康复设施在UVM校园，和步行回家变量的运动。 强有力的证据支持运动和改善冠状动脉危险因素（胆固醇，血压等）。可以显著减少致命和非致命的冠状动脉事件，改善生活质量，并增加冠心病患者的预期寿命。 在这项研究中，我们将重点关注减肥和运动对降低未来心脏问题风险的价值。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to study the effectiveness of a low calorie diet and two different types of exercise on weight control in overweight patients with Coronary Heart Disease (CHD). We will also closely measure the benefits of weight loss as it relates to measures that predict risk of further cardiac problems. These include cholesterol profiles, measures of glucose metabolism, body fat distribution and measures of blood clotting. Methods of weight loss and subsequent benefits in people with CHD have not been very well studied. We propose to study the effectiveness of: 1. A behaviorally-based weight loss program characterized by a daily calorie-intake goal and substantial behavioral and social support to attain dietary goals, and 2. Either of 2 types of supplementary exercise programs to assist with the weight loss intervention. These are characterized by variable amounts of exercise at our Cardiac Rehabilitation facility on the UVM campus, and home-walking. Strong evidence supports that exercise and improved coronary risk factors (cholesterol, blood pressure etc.) can significantly contribute to a reduction of fatal and non-fatal coronary events, an improved quality of life, and an increased life expectancy for people with coronary heart disease. In this study we will focus on the value of weight loss and exercise on decreasing future risk of heart problems.