METHODS OF WEIGHT LOSS IN OVERWEIGHT PATIENTS WITH CORONARY HEART DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究的目的是研究低热量饮食和两种不同类型的运动对超重冠心病(CHD)患者体重控制的有效性。我们还将密切衡量减肥的好处，因为它与预测进一步心脏问题风险的措施有关。这些指标包括胆固醇、葡萄糖新陈代谢指标、体脂分布和血液凝结指标。 冠心病患者的减肥方法和随后的益处还没有得到很好的研究。我们建议研究以下措施的成效： 1.以行为为基础的减肥计划，其特点是每日卡路里摄取目标和为实现饮食目标而提供的大量行为和社会支持，以及 2.两种辅助运动计划中的任何一种，以协助减肥干预。这些活动的特点是在我们位于威斯康星大学校园的心脏康复设施进行不同量的锻炼，以及步行回家。 强有力的证据支持锻炼和改善冠状动脉风险因素(胆固醇、血压等)。可显著减少致命性和非致命性冠状动脉事件，提高生活质量，延长冠心病患者的预期寿命。在这项研究中，我们将重点关注减肥和锻炼在降低未来心脏问题风险方面的价值。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to study the effectiveness of a low calorie diet and two different types of exercise on weight control in overweight patients with Coronary Heart Disease (CHD). We will also closely measure the benefits of weight loss as it relates to measures that predict risk of further cardiac problems. These include cholesterol profiles, measures of glucose metabolism, body fat distribution and measures of blood clotting. Methods of weight loss and subsequent benefits in people with CHD have not been very well studied. We propose to study the effectiveness of: 1. A behaviorally-based weight loss program characterized by a daily calorie-intake goal and substantial behavioral and social support to attain dietary goals, and 2. Either of 2 types of supplementary exercise programs to assist with the weight loss intervention. These are characterized by variable amounts of exercise at our Cardiac Rehabilitation facility on the UVM campus, and home-walking. Strong evidence supports that exercise and improved coronary risk factors (cholesterol, blood pressure etc.) can significantly contribute to a reduction of fatal and non-fatal coronary events, an improved quality of life, and an increased life expectancy for people with coronary heart disease. In this study we will focus on the value of weight loss and exercise on decreasing future risk of heart problems.