USING GFR TO MEASURE THE EFFECT OF RADIO-OPAQUE CONTRAST MEDIA ON RENAL FUNCTIO

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。放射不透明造影剂（CM）可以通过血清肌酐的变化来测定肾毒性。然而，直到肾小球滤过率（GFR）显著降低，这个值才会改变。因此，毒性的发生率可能被低估了。本研究将确定CM诱导GFR的变化。研究前3小时，测定GFR。研究人员将使用少量的CM，并在三小时后通过一种经过验证的方法分析血浆浓度。他们将研究30名患者，其中没有人已知有肾功能障碍。这项研究是最近开始的；目前还没有结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Radio-opaque contrast media (CM) can be nephrotoxic, as measured by changes in serum creatinine. However, this value does not change until the glomerular filtration rate (GFR) is significantly lowered. Hence, the incidence of toxicity may be underestimated. This study will determine changes in GFR induced by CM. Three hours prior to the study, GFR will be determined. The investigators will use small amounts of CM and analyze plasma concentration three hours later by a validated method. They will study 30 patients, none of whom have known renal dysfunction. This study was recently initiated; no results are yet available.