USING GFR TO MEASURE THE EFFECT OF RADIO-OPAQUE CONTRAST MEDIA ON RENAL FUNCTIO

使用 GFR 测量不透射线造影剂对肾功能的影响

• 批准号: 7718403
• 负责人: JOSHUA BECKER
• 金额: $ 0.73万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718403
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Contrast Media; Creatinine; Functional disorder; Funding; Glomerular Filtration Rate; Grant; Hour; Incidence; Institution; Kidney; Measures; Methods; Nephrotoxic; Patients; Plasma; Radio-Opaque; Research; Research Personnel; Resources; Serum; Source; Toxic effect; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Radio-opaque contrast media (CM) can be nephrotoxic, as measured by changes in serum creatinine. However, this value does not change until the glomerular filtration rate (GFR) is significantly lowered. Hence, the incidence of toxicity may be underestimated. This study will determine changes in GFR induced by CM. Three hours prior to the study, GFR will be determined. The investigators will use small amounts of CM and analyze plasma concentration three hours later by a validated method. They will study 30 patients, none of whom have known renal dysfunction. This study was recently initiated; no results are yet available.

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