USING GFR TO MEASURE THE EFFECT OF RADIO-OPAQUE CONTRAST MEDIA ON RENAL FUNCTIO

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 不透射线造影剂（CM）可能具有肾毒性，可通过血清肌酐的变化进行测量。 然而，这个值不会改变，直到肾小球滤过率（GFR）显着降低。 因此，毒性的发生率可能被低估。 本研究将确定CM诱导的GFR变化。 研究前3小时，将测定GFR。 研究者将使用少量CM，并在3小时后通过经验证的方法分析血浆浓度。 他们将研究30名患者，其中没有一个已知的肾功能不全。 这项研究是最近开始的;目前尚无结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Radio-opaque contrast media (CM) can be nephrotoxic, as measured by changes in serum creatinine. However, this value does not change until the glomerular filtration rate (GFR) is significantly lowered. Hence, the incidence of toxicity may be underestimated. This study will determine changes in GFR induced by CM. Three hours prior to the study, GFR will be determined. The investigators will use small amounts of CM and analyze plasma concentration three hours later by a validated method. They will study 30 patients, none of whom have known renal dysfunction. This study was recently initiated; no results are yet available.