THE ROLE OF INFLAMMATORY POLYMORPHISMS IN COLORECTAL NEOPLASIA

炎症多态性在结直肠肿瘤中的作用

• 批准号: 7378309
• 负责人: FRITZ FRANCOIS
• 金额: $ 7.76万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378309
• 关键词: ROLE; INFLAMMATORY; POLYMORPHISMS; COLORECTAL; NEOPLASIA

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The investigators propose to obtain blood from approximately 500 patients scheduled for screening colonoscopy. The blood samples will be analyzed for pro-inflammatory cytokines. Polymorphisms in pro-inflammatory cytokines are associated with increased risk of gastric cancer. The hypothesis of this pilot, exploratory study is that there is a similar increased risk in the development of carcinoma of the colon. The investigators propose to obtain blood from approximately 500 patients scheduled for screening colonoscopy. The blood samples will be analyzed for pro-inflammatory cytokines: COX-2, IL-1b, IL-2, IL-6, IL-8, IL-10, PPARg, and TNFa. They plan to examine patients for history of red meat consumption, BMI, history of cancer, etc; colonoscopy; and allelic analysis. Subjects will be stratified into four populations: no polyps; low-grade polyps; high-grade polyps; colorectal cancer. Preliminary data show significance.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。研究人员建议从大约500名计划进行结肠镜检查的患者中获取血液。血样将被用于分析促炎细胞因子。促炎细胞因子的多态性与胃癌风险增加有关。这个初步的探索性研究的假设是，在结肠癌的发展中也有类似的风险增加。研究人员建议从大约500名计划进行结肠镜检查的患者中获取血液。血液样本将分析促炎细胞因子：COX-2、IL-1b、IL-2、IL-6、IL-8、IL-10、ppar和TNFa。他们计划检查患者的红肉消费史、身体质量指数、癌症史等；结肠镜检查;还有等位基因分析。受试者将被分为四组：没有息肉；低级的息肉;高档息肉;结直肠癌。初步数据显示了显著性。