ASSESSING THE IN-VIVO INTERACTION BETWEEN THE ENTEROINSULAR AXIS AND AUTONOMI

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究的目的是评估和比较有和没有普拉德-威利综合征（PWS）的超重青少年，这是一种以精神和身体异常为特征的遗传性疾病。它将评估体内过量脂肪，脂肪分布，激素水平和神经系统活动之间的相互作用，并将分析有和没有PWS的儿童中肥胖和肥胖相关并发症的发展机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to evaluate and compare overweight adolescents with and without Prader-Willi Syndrome (PWS), a genetic disorder characterized by mental and physical abnormalities. It will assess the interaction between excessive fat in the body, fat distribution, hormone levels and nervous system activity, and will analyze the mechanisms involved in the development of obesity and obesity-related complications in children with and without PWS.