ASSESSING THE IN-VIVO INTERACTION BETWEEN THE ENTEROINSULAR AXIS AND AUTONOMI

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的目的是评估和比较患有和不患有Prader-Willi综合征(PWS)的超重青少年，PWS是一种以精神和身体异常为特征的遗传性疾病。它将评估体内过多脂肪、脂肪分布、激素水平和神经系统活动之间的相互作用，并将分析患有和不患有PWS的儿童肥胖和肥胖相关并发症的发生机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to evaluate and compare overweight adolescents with and without Prader-Willi Syndrome (PWS), a genetic disorder characterized by mental and physical abnormalities. It will assess the interaction between excessive fat in the body, fat distribution, hormone levels and nervous system activity, and will analyze the mechanisms involved in the development of obesity and obesity-related complications in children with and without PWS.