METABOLIC OUTCOME AFTER ISLET TRANSPLANTATION IN T1DM: A PILOT STUDY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。该试点项目的总体目标是确定胰岛细胞移植对1型糖尿病患者的代谢结果，包括移植后至少9个月的正常血糖恢复、胰岛素分泌刺激、胰岛素脉搏和肝脏胰岛素敏感性。我们将在先前在明尼苏达大学移植的受试者中评估这些参数，作为试点项目，作为未来对移植前后新患者进行前瞻性研究的基础，以比较免疫抑制方案。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall aim of this pilot project is to determine the metabolic outcome of pancreatic islet cell transplantation in subjects with type 1 diabetes with regards to restoration of euglycemia, stimulated insulin secretion, insulin pulsatility, and hepatic insulin sensitivity at least nine months aftrer transplatation. We will evaluate these parameters in subjects previously transplanted at the University of Minnesota as a pilot project, as a basis for future prospective studies on new patients before and after transplantation to compare immunosuppressive protocols.