EVALUATION OF THE RELATION BETWEEN TPN COMPOSITION AND HYPERGLYCEMIA AND THE

TPN 组合物与高血糖之间关系的评估

• 批准号: 7374952
• 负责人: Agneta Lisbeth Sunehag
• 金额: $ 0.88万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374952
• 关键词: EVALUATION; RELATION; BETWEEN; TPN; COMPOSITION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hyperglycemia is frequently occurring in very premature infants receiving TPN. Incidence figures of 50-80% have been reported. Most of these studies are, however, 10-15 years old. Hyperglycemia has been associated with the degree of prematurity, infusion rates of glucose, illness e.g. sepsis. It has also been associated with osmotic diuresis, urinary gulcose loss, hyperosmolarity and cerebral bleedings. There is controversy regarding 1) the true relations between the above factors and hyperglycemia; 2) the real risks associated with hyperglycemia; 3) threshold for "acceptable" hyperglycemia; 4) effects of treatment such as insulin; 5) the incidence of hypoglycemia during insulin treatment. The nutritional treatment of very premature infants has changed over the past 5 years, specifically, parenteral amino acids and lipids are now introduced within the first days of birth and the infusion rates are increased rapidly. Thus, as a part of our attempts to optimize the nutritional treatment of these small infants, it is important to evaluate the impact of nutrition and other factors on the development of hyperglycemia, and also the long term effects of different degrees of hyperglycemia.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。高血压经常发生在接受TPN的极早产儿中。据报道，发病率为50-80%。然而，这些研究大多是10-15年前的。高血压与早产程度、葡萄糖输注速率、疾病（例如败血症）相关。它还与渗透性利尿、尿葡萄糖丢失、高渗和脑出血有关。关于1）上述因素与高血糖症之间的真实关系; 2）与高血糖症相关的真实的风险; 3）“可接受”高血糖症的阈值; 4）胰岛素等治疗的影响; 5）胰岛素治疗期间低血糖症的发生率存在争议。在过去5年中，极早产儿的营养治疗发生了变化，特别是，现在在出生后的最初几天内引入肠外氨基酸和脂质，并且输注速率迅速增加。因此，作为我们尝试优化这些小婴儿的营养治疗的一部分，重要的是评估营养和其他因素对高血糖症发展的影响，以及不同程度的高血糖症的长期影响。