CLINICAL TRIAL: DIETARY MACRONUTRIENT INTAKE AND EXERCISE ON GLUCOSE AND INSULIN
临床试验:膳食大量营养素摄入量以及葡萄糖和胰岛素的锻炼
基本信息
- 批准号:8166653
- 负责人:
- 金额:$ 2.44万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-12-01 至 2010-11-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdolescentArtsBody fatCalorimetryCarbohydratesChildChildhoodClinical TrialsComputer Retrieval of Information on Scientific Projects DatabaseDataDevelopmentDietEnergy MetabolismEtiologyExerciseFatty acid glycerol estersFundingGluconeogenesisGlucoseGrantImpairmentIncidenceInstitutionInsulinIntakeLeadLipidsLipolysisMacronutrients NutritionMagnetic Resonance ImagingMetabolicModerate ExerciseNon obeseNon-Insulin-Dependent Diabetes MellitusObesityOverweightPhysical activityPrevalenceResearchResearch PersonnelResourcesRiskSourceTechniquesUnited States National Institutes of Healthglucose metabolismglucose productionglycogenolysisimprovedinsulin secretionoxidationpreventprogramsstable isotopetype 2 diabetes in children
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Over the past 30 years the prevalence of overweight children (6-19 y) in the USA (BMI>95th percentile) has increased 3-fold to reach 13-14% in 1999. Concomitant with the increase in childhood overweight, the incidence of type 2 diabetes in children (0-19 y) has increased 4-fold. Although the etiology of obesity related impairment of glucose metabolism is multifactorial, dietary macronutrient intake and physical activity are potentially important factors. The aims of this proposal are to determine in healthy adolescents 1) the impact of obesity on energy expenditure and substrate oxidation, glucose production from gluconeogenesis and glycogenolysis, insulin secretion and sensitivity and lipolysis; 2) whether a 12 weeks moderate exercise program will improve glucose metabolism in obese adolescents, and if so, 3) whether the exercise effect is correlated with a decrease in intramyocellular fat content and/or increased lipid oxidation, and 4) whether dietary macronutrient composition of the diet impacts metabolic effects of exercise. To address these questions, 24 over weight (body fat >30%) and 24 non-obese (body fat <26%) adolescents will be studied on three occasions (just prior to the start of a 12 weeks exercise program, 6 weeks into the program and during the last week of exercise); in 24 subjects,12 obese and 12 non-obese, each of the three study occasions will be preceded by 7-d of a high carbohydrate diet, and in the other 24 of a 7-d high fat diet. State of the art stable isotope-GCMS techniques, MRI and 24 h room calorimetry will be used to obtain the data needed to address the aims stated above. The information provided by these studies will improve our understanding of the metabolic effects of obesity in adolescents and will lead to identifying factors, which may increase the risk of type 2 diabetes or prevent or delay the development of type 2 diabetes in adolescents.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
在过去的30年里,美国超重儿童(6-19岁)的患病率(BMI>第95百分位数)增加了3倍,1999年达到13-14%。随着儿童超重的增加,儿童(0-19岁)2型糖尿病的发病率增加了4倍。虽然肥胖相关的糖代谢障碍的病因是多因素的,但膳食大量营养素摄入和体力活动是潜在的重要因素。该建议的目的是在健康青少年中确定1)肥胖对能量消耗和底物氧化、由糖原生成和糖原分解产生的葡萄糖、胰岛素分泌和敏感性以及脂解的影响; 2)12周的适度运动计划是否会改善肥胖青少年的葡萄糖代谢,如果是,3)运动效果是否与肌细胞内脂肪含量的降低和/或脂质氧化的增加相关,以及4)饮食的膳食常量营养素组成是否影响运动的代谢效果。 为了解决这些问题,24超重(体脂>30%)和24名非肥胖者(体脂<26%)青少年将在三个场合进行研究(就在12周锻炼计划开始之前,进入计划的6周以及锻炼的最后一周期间);在24名受试者(12名肥胖者和12名非肥胖者)中,三次研究中的每一次都将在7天高碳水化合物饮食之前进行,而在其他24名受试者中,将在7天高脂肪饮食之前进行。将使用最先进的稳定同位素-GCMS技术、MRI和24小时室内量热法获得实现上述目标所需的数据。这些研究提供的信息将提高我们对青少年肥胖代谢影响的理解,并将导致识别可能增加2型糖尿病风险或预防或延迟青少年2型糖尿病发展的因素。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Agneta Lisbeth Sunehag其他文献
Agneta Lisbeth Sunehag的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Agneta Lisbeth Sunehag', 18)}}的其他基金
IMPACT OF TOTAL BODY FAT IN SEDENTARY HISPANIC ADOLESCENTS WITH NORMAL BMI
身体总脂肪对 BMI 正常、久坐不动的西班牙裔青少年的影响
- 批准号:
8356690 - 财政年份:2010
- 资助金额:
$ 2.44万 - 项目类别:
IMPACT OF TOTAL BODY FAT IN SEDENTARY HISPANIC ADOLESCENTS WITH NORMAL BMI
身体总脂肪对 BMI 正常、久坐不动的西班牙裔青少年的影响
- 批准号:
8166705 - 财政年份:2009
- 资助金额:
$ 2.44万 - 项目类别:
IMPACT OF REDUCED GLUCOSE INFUSION RATE AND INSULIN INFUSION, RESPECTIVELY, O
分别降低葡萄糖输注速度和胰岛素输注的影响,O
- 批准号:
8166664 - 财政年份:2009
- 资助金额:
$ 2.44万 - 项目类别:
EFFECTS OF DIETARY MACRONUTRIENT INTAKE AND RESISTANCE TRAINING EXERCISE ON G
膳食大量营养素摄入量和抗阻训练对体重的影响
- 批准号:
8166668 - 财政年份:2009
- 资助金额:
$ 2.44万 - 项目类别:
IMPACT OF TOTAL BODY FAT IN SEDENTARY HISPANIC
总脂肪对久坐的西班牙裔人的影响
- 批准号:
7950658 - 财政年份:2008
- 资助金额:
$ 2.44万 - 项目类别:
IMPACT OF REDUCED GLUCOSE INFUSION RATE AND INSULIN INFUSION, RESPECTIVELY, O
分别降低葡萄糖输注速度和胰岛素输注的影响,O
- 批准号:
7950603 - 财政年份:2008
- 资助金额:
$ 2.44万 - 项目类别:
EFFECTS OF DIETARY MACRONUTRIENT INTAKE AND RESISTANCE TRAINING EXERCISE ON G
膳食大量营养素摄入量和抗阻训练对体重的影响
- 批准号:
7950609 - 财政年份:2008
- 资助金额:
$ 2.44万 - 项目类别:
CLINICAL TRIAL: DIETARY MACRONUTRIENT INTAKE AND EXERCISE ON GLUCOSE AND INSULIN
临床试验:膳食大量营养素摄入量以及葡萄糖和胰岛素的锻炼
- 批准号:
7950589 - 财政年份:2008
- 资助金额:
$ 2.44万 - 项目类别:
EFFECTS OF DIETARY MACRONUTRIENT INTAKE AND RESISTANCE TRAINING EXERCISE ON G
膳食大量营养素摄入量和抗阻训练对体重的影响
- 批准号:
7605897 - 财政年份:2007
- 资助金额:
$ 2.44万 - 项目类别:
DIETARY MACRONUTRIENT INTAKE AND EXERCISE ON GLUCOSE AND INSULIN KINETICS
膳食大量营养素摄入量和运动对葡萄糖和胰岛素动力学的影响
- 批准号:
7605851 - 财政年份:2007
- 资助金额:
$ 2.44万 - 项目类别:
相似海外基金
Exploring the mental health and wellbeing of adolescent parent families affected by HIV in South Africa
探讨南非受艾滋病毒影响的青少年父母家庭的心理健康和福祉
- 批准号:
ES/Y00860X/1 - 财政年份:2024
- 资助金额:
$ 2.44万 - 项目类别:
Fellowship
Scaling-up co-designed adolescent mental health interventions
扩大共同设计的青少年心理健康干预措施
- 批准号:
MR/Y020286/1 - 财政年份:2024
- 资助金额:
$ 2.44万 - 项目类别:
Fellowship
Shared Spaces: The How, When, and Why of Adolescent Intergroup Interactions
共享空间:青少年群体间互动的方式、时间和原因
- 批准号:
ES/T014709/2 - 财政年份:2024
- 资助金额:
$ 2.44万 - 项目类别:
Research Grant
Social Media Mechanisms Affecting Adolescent Mental Health (SoMe3)
影响青少年心理健康的社交媒体机制 (SoMe3)
- 批准号:
MR/X034925/1 - 财政年份:2024
- 资助金额:
$ 2.44万 - 项目类别:
Fellowship
Parent-adolescent informant discrepancies: Predicting suicide risk and treatment outcomes
父母与青少年信息差异:预测自杀风险和治疗结果
- 批准号:
10751263 - 财政年份:2024
- 资助金额:
$ 2.44万 - 项目类别:
Adolescent sugar overconsumption programs food choices via altered dopamine signalling
青少年糖过度消费通过改变多巴胺信号来影响食物选择
- 批准号:
BB/Y006496/1 - 财政年份:2024
- 资助金额:
$ 2.44万 - 项目类别:
Research Grant
The Impact of Online Social Interactions on Adolescent Cognition
在线社交互动对青少年认知的影响
- 批准号:
DE240101039 - 财政年份:2024
- 资助金额:
$ 2.44万 - 项目类别:
Discovery Early Career Researcher Award
Resilience Factors, Pain, and Physical Activity in Adolescent Chronic Musculoskeletal Pain
青少年慢性肌肉骨骼疼痛的弹性因素、疼痛和体力活动
- 批准号:
10984668 - 财政年份:2024
- 资助金额:
$ 2.44万 - 项目类别:
Augmented Social Play (ASP): smartphone-enabled group psychotherapeutic interventions that boost adolescent mental health by supporting real-world connection and sense of belonging
增强社交游戏 (ASP):智能手机支持的团体心理治疗干预措施,通过支持现实世界的联系和归属感来促进青少年心理健康
- 批准号:
10077933 - 财政年份:2023
- 资助金额:
$ 2.44万 - 项目类别:
EU-Funded
Family-Focused Adolescent & Lifelong Health Promotion (FLOURISH)
以家庭为中心的青少年
- 批准号:
10050850 - 财政年份:2023
- 资助金额:
$ 2.44万 - 项目类别:
EU-Funded