IMPACT OF TOTAL BODY FAT IN SEDENTARY HISPANIC

总脂肪对久坐的西班牙裔人的影响

• 批准号: 7950658
• 负责人: Agneta Lisbeth Sunehag
• 金额: $ 0.21万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950658
• 关键词: Address; Adolescent; Age; Body fat; Body mass index; Child; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Dual-Energy X-Ray Absorptiometry; Fasting; Fatty acid glycerol esters; Funding; Grant; Guidelines; Height; Hepatic; Hispanics; Institution; Insulin; Insulin Resistance; Lead; Magnetic Resonance Imaging; Measures; Methods; National Health and Nutrition Examination Survey; Normal Range; OGTT; Obesity; Obesity associated disease; Overweight; Population; Prevalence; Protocols documentation; Public Health; Reporting; Research; Research Personnel; Resources; Screening procedure; Source; Testing; United States National Institutes of Health; Visceral; Weight; age group; blood glucose regulation; boys; girls; insulin sensitivity; prevent; sedentary

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The National Health and Nutrition Examination Surveys, NHANES II and III, report an increasing prevalence of overweight and obesity as well as of obesity related diseases in children. This is a serious public health problem necessitating research to determine which factors lead to obesity and which strategies could be used to prevent and treat obesity and its consequences. Most of the research conducted to address these issues requires comparison between obese and lean subjects. In order to provide accurate conclusions, the definition of "lean" and "obese" must be absolutely clear. The most routinely used criteria to distinguish lean from obese subjects is body mass index (BMI) i.e. weight in kg/ height in m2. However, a BMI within the normal range for age might result in heterogeneous groups, including subjects with both low and high body fat percentage, low and high visceral fat and low and high hepatic fat content. All of these factors might confound results and conclusions. In this protocol we will explore whether there is a correlation between body fat percentage (measured by DXA), visceral adiposity (measured by MRI), hepatic fat content (measured by MRI) and insulin sensitivity (assessed by fasting insulin and an Oral Glucose Tolerance Test (OGTT) in adolescents with normal BMI (below the 85th percentile i.e. 25 kg/m2 in the planned age group) and body fat percentage equal to or above 27% in girls and 25% in boys. These results will be compared with those of our ongoing study (H-11954)including strictly lean and obese subjects Collectively the information from this proposed protocol and the ongoing study, will enable us to define the influence of BMI, body fat percentage and fat distribution on insulin sensitivity and glucose homeostasis in adolescents, which will in turn provide guidelines for optimizing screening methods in studies on obesity. HYPOTHESIS Overall hypothesis Using BMI as the only criteria to define lean subjects results in a mix of subjects with both normal and high body fat percentage. Subjects with high body fat percentage contain both insulin sensitive and insulin resistant subjects. Insulin sensitivity is related to their visceral fat content. Specific hypotheses In a population of adolescents with normal BMI, but high body fat percentage, some subjects will have low and some high visceral fat content, and this population will contain both insulin sensitive and insulin resistant subjects. In adolescents with normal BMI and high body fat percentage, insulin sensitivity is correlated with visceral fat content. In adolescents with normal BMI and high body fat percentage, visceral fat correlates with hepatic fat content. SPECIFIC AIMS To test the hypotheses stated above.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 NHANES II和III的国家健康和营养检查调查报告说，超重和肥胖的患病率越来越多，以及儿童肥胖相关的疾病。这是一个严重的公共卫生问题，需要研究以确定哪些因素导致肥胖症以及哪些策略可用于预防和治疗肥胖及其后果。为解决这些问题而进行的大多数研究都需要在肥胖和精益受试者之间进行比较。为了提供准确的结论，必须绝对清楚“精益”和“肥胖”的定义。区分瘦肉和肥胖受试者的最常用的标准是体重指数（BMI），即M2中的重量/高度。但是，年龄正常范围内的BMI可能会导致异质组，包括低体内脂肪百分比，低和高内脏脂肪以及低肝脂肪含量和高肝脂肪含量的受试者。所有这些因素可能会混淆结果和结论。 在该协议中，我们将探讨体内脂肪百分比（通过DXA测量），内脏肥胖（通过MRI测量），肝脂肪含量（通过MRI测量）和胰岛素敏感性（通过禁食胰岛素和口服葡萄糖耐受性测试（OGTT）在正常BMI中（下面）In.25 55 in.mmi（以下）。年龄组和身体脂肪百分比等于或以上等于或高于27％的男孩和25％的男孩。优化肥胖研究中的筛查方法。 假设 总体假设 使用BMI作为定义精益受试者的唯一标准会导致与正常脂肪百分比的受试者混合在一起。体内脂肪百分比高的受试者既包含胰岛素敏感和胰岛素耐药受试者）。胰岛素敏感性与它们的内脏脂肪含量有关。 特定的假设 在BMI正常但体内高脂肪百分比的青少年人群中，某些受试者的内脏脂肪含量较低，并且该人群将包含胰岛素敏感和胰岛素耐药的受试者。 在正常BMI和高体内脂肪百分比的青少年中，胰岛素敏感性与内脏脂肪含量相关。 在正常BMI和高体内脂肪百分比的青少年中，内脏脂肪与肝脂肪含量相关。 具体目标 测试上述假设。