IMPACT OF TOTAL BODY FAT IN SEDENTARY HISPANIC ADOLESCENTS WITH NORMAL BMI

身体总脂肪对 BMI 正常、久坐不动的西班牙裔青少年的影响

• 批准号: 8356690
• 负责人: Agneta Lisbeth Sunehag
• 金额: $ 0.4万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356690
• 关键词: Address; Adolescent; Age; Body fat; Body mass index; Child; Clinical Research; Dual-Energy X-Ray Absorptiometry; Fasting; Fatty acid glycerol esters; Funding; Grant; Guidelines; Height; Hepatic; Hispanics; Insulin; Lead; Magnetic Resonance Imaging; Measures; Methods; National Center for Research Resources; National Health and Nutrition Examination Survey; Normal Range; OGTT; Obesity; Obesity associated disease; Overweight; Prevalence; Principal Investigator; Protocols documentation; Public Health; Reporting; Research; Research Infrastructure; Resources; Screening procedure; Source; United States National Institutes of Health; Visceral; Weight; age group; blood glucose regulation; boys; cost; girls; insulin sensitivity; prevent; sedentary

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ABSTRACT The National Health and Nutrition Examination Surveys, NHANES II and III, report an increasing prevalence of overweight and obesity as well as of obesity related diseases in children. This is a serious public health problem necessitating research to determine which factors lead to obesity and which strategies could be used to prevent and treat obesity and its consequences. Most of the research conducted to address these issues requires comparison between obese and lean subjects. In order to provide accurate conclusions, the definition of "lean" and "obese" must be absolutely clear. The most routinely used criteria to distinguish lean from obese subjects is body mass index (BMI) i.e. weight in kg/ height in m2. However, a BMI within the normal range for age might result in heterogeneous groups, including subjects with both low and high body fat percentage, low and high visceral fat and low and high hepatic fat content. All of these factors might confound results and conclusions. In this protocol we will explore whether there is a correlation between body fat percentage (measured by DXA), visceral adiposity (measured by MRI), hepatic fat content (measured by MRI) and insulin sensitivity (assessed by fasting insulin and an Oral Glucose Tolerance Test (OGTT)) in adolescents with normal BMI (below the 85th percentile i.e. 25 kg/m2 in the planned age group) and body fat percentage equal to or above 27% in girls and 25% in boys. These results will be compared with those of our ongoing study (H-11954) including strictly lean and obese subjects Collectively the information from this proposed protocol and the ongoing study, will enable us to define the influence of BMI, body fat percentage and fat distribution on insulin sensitivity and glucose homeostasis in adolescents, which will in turn provide guidelines for optimizing screening methods in studies on obesity.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 抽象的 NHANES II和III的国家健康和营养检查调查报告说，超重和肥胖的患病率越来越多，以及儿童肥胖相关的疾病。这是一个严重的公共卫生问题，需要研究以确定哪些因素导致肥胖症以及哪些策略可用于预防和治疗肥胖及其后果。为解决这些问题而进行的大多数研究都需要在肥胖和精益受试者之间进行比较。为了提供准确的结论，必须绝对清楚“精益”和“肥胖”的定义。区分瘦肉和肥胖受试者的最常用的标准是体重指数（BMI），即M2中的重量/高度。但是，年龄正常范围内的BMI可能会导致异质组，包括低体内脂肪百分比，低和高内脏脂肪以及低肝脂肪含量和高肝脂肪含量的受试者。所有这些因素可能会混淆结果和结论。 在该协议中，我们将探讨体内脂肪百分比（通过DXA测量），内脏肥胖（通过MRI测量），肝脂肪含量（通过MRI测量）和胰岛素敏感性（通过禁食胰岛素和口服葡萄糖耐受性测试（OGTT）评估的25.25 ir.2555555555555555555555555555555555555年评估。计划的年龄组）和男孩的体内脂肪百分比等于或高于或高于27％，男孩为25％。这些结果将与我们正在进行的研究（H-11954）的结果进行比较，包括严格的瘦肉和肥胖的受试者，从该拟议方案和正在进行的研究中共同将信息进行比较，将使我们能够定义BMI，身体脂肪百分比和脂肪分布对胰岛素敏感性和葡萄糖稳态的影响，从而为少数人提供了对指导的启发，从而使对临床的启发进行了研究。