THE REMOVAL OF CIRCULATING TOXINS DURING HEMODIALYSIS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。肾功能衰竭患者血液循环中有许多有害分子和促炎细胞因子过多，需要血液透析治疗。我们已经确定了三种可能刺激和维持这些患者炎症状态的蛋白质：HMGB1、游离血红蛋白和S100A8。这项研究将着眼于透析治疗过程中这三种分析物的循环水平。然后，研究将这些分析物的浓度与患者的“幸福感”联系起来，通过一个简短的问卷来描述。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Patients with renal failure have an overabundance of many harmful molecules and proinflammatory cytokines in circulation and are treated by hemodialysis. We have identified three putative proteins that have the potential for stimulating and maintaining an inflammatory state in these patients: HMGB1, free hemoglobin, and S100A8. This study will look at the circulating levels of these three analytes over the course of dialysis treatment. The study will then correlate the concentrations of these analytes in circulation with the patients' feeling of "well-being", as described by a short questionnaire.