EFFECT OF AURICULAR VAGUS NERVE STIMULATION ON HEART RATE VARIABILITY IN HEALTHY

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 胆碱能抗炎通路是自主神经系统，特别是迷走神经，调节宿主炎症反应的机制。 在本方案中，我们将研究经皮刺激迷走神经耳分支对迷走神经张力的影响，通过心率变异性进行测量。 我们将研究不同刺激位置、持续时间和技术获得的反应幅度，以及昼夜节律的影响。 这些信息将为我们提供最佳的刺激参数，用于未来的试验，观察经皮迷走神经刺激对炎症性疾病的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The cholinergic anti-inflammitory pathway is a mechanism through which the autonomic nervous system, specifically the vagus nerve, regulates the host inflammatory response. In this protocol we will investigate the effect of transcutaneous stimulation of the auricular branch of the vagus nerve on vagal tone, as measured by heart rate variability. We will study the magnitude of response obtained with different stimulation location, duration, and technique, as well as the impact of circadian rhythm. This information will provide us with the optimal stimulation parameters for use in future trials looking at the effect of transcutaneous vagus stimulation on inflammatory disease.