FAMILIAL SCHIZOPHRENIA SPECTRUM PERSONALITY DISORDERS

家族性精神分裂症谱系人格障碍

• 批准号: 3389107
• 负责人: GUNVANT K THAKER
• 金额: $ 12.67万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE COUNTY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-05-01 至 1997-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3389107
• 关键词: attention; biomarker; eye movements; family genetics; mental disorder diagnosis; psychobiology; schizoid personality; smooth pursuit eye movement; young adult human (21-34)

The studies of biological markers for genetic vulnerability to schizophrenia, which test an association between a biological measure and schizotypal symptoms, are constrained since these symptoms may lack the specificity for the schizophrenic phenotype. Although family studies of schizophrenic probands validate a familial link between schizophrenia and e schizophrenia spectrum personality (SSPD) traits, the same personality styles may or may not be related to schizophrenia when they occur in an individual who does not have a family history of schizophrenia. Environmental and other genetic factors contribute to the origins of such subtle symptoms in non-familial SSPD individuals. Therefore, an association between a biological measure and these symptoms in the non-- familial SSPD can easily be false (i.e. not related to schizophrenic vulnerability). Such an association can occur for a number of spurious reasons, for instance the symptoms of SSPD themselves may effect the biological measure. In contrast, a strongly deviant finding in the familial SSPD subjects, in the presence of a normal finding (or mildly deviant finding to the extent of the schizophrenic genetic contribution) in the nonfamilial SSPD, makes the biological marker a worthwhile candidate for such investigations. In this case, any spurious association between the phenomena of SSPD and the biological measure can be ruled out. We plan to recruit: familial SSPD subjects (n=30), non-familial SSPD subjects (n=30), and familial (n=30) and non-familial (n=30) controls with no SSPD diagnoses. All groups will be matched on socio-demographic variables. The familial subjects will be recruited from the family members of schizophrenic patients and the non-familial subjects from the community. The following biological measures will be tests to evaluate the psychobiology of SSPD and test putative vulnerability markers: 1) Specific oculomotor measures will be obtained during fixation, smooth pursuit and saccadic tasks. Measures of shift in visual attention independent of eye movements will also be collected through Posner's and specific saccadic eye movement paradigms. 2) Other measures of sustained visual attention in a continuous performance (CPT) will be collected.

遗传易感性的生物学标记研究 精神分裂症，它测试生物测量和 非典型症状，是有限的，因为这些症状可能缺乏 对精神分裂症表型的特异性。 虽然家庭研究 精神分裂症先证者证实了精神分裂症与 e精神分裂症谱系人格（SSPD）特征，相同的人格 风格可能与精神分裂症有关，也可能与精神分裂症无关， 没有精神分裂症家族史的人。 环境和其他遗传因素有助于这种疾病的起源。 非家族性SSPD个体的轻微症状。 所以一间 生物测量和这些症状之间的联系， 家族性SSPD很容易是假的（即与精神分裂症无关）。 脆弱性）。 这种关联可以发生在许多虚假的 原因，例如SSPD的症状本身可能会影响 生物措施。 与此相反，一个强烈的异常发现， 家族性SSPD受试者，在存在正常发现（或轻度 精神分裂症遗传贡献程度的异常发现） 在非家族性SSPD中，使生物标记物成为一种有价值的 这类调查的候选人。 在这种情况下， SSPD现象与生物学测量之间的关联可以 被排除在外 我们计划招募：家族性SSPD受试者（n=30）， 非家族性SSPD受试者（n=30），以及家族性（n=30）和非家族性 （n=30）无SSPD诊断的对照组。 所有组将在 社会人口变量。 将招募家族受试者 精神分裂症患者的家庭成员和非家庭成员 从社区的主题。 将采取以下生物措施 评估SSPD的心理生物学的测试和测试假定的 脆弱性标记：1）将获得特定的眼科测量结果 在注视、平滑追踪和扫视任务期间。 转移措施 也将收集独立于眼球运动的视觉注意力 通过波斯纳的和特定的扫视眼球运动范例。2)其他 持续性视觉注意（CPT） 将被收集。