FAMILIAL SCHIZOPHRENIA SPECTRUM PERSONALITY DISORDERS

遗传易感性的生物标记研究进展 精神分裂症，它测试了生物测量和 分裂型症状，因为这些症状可能缺乏 精神分裂症表型的特异性。虽然家族性研究 精神分裂症先证者证实精神分裂症和 精神分裂症谱系人格(SSPD)特征，相同的人格 风格可能与精神分裂症有关也可能与精神分裂症无关 没有精神分裂症家族史的个人。 环境和其他遗传因素促成了这种现象的起源 非家族性SSPD患者的细微症状。因此，一个 生物测量和这些症状在非-- 家族性SSPD很容易是假的(即与精神分裂症无关 漏洞)。这种关联可能发生在许多虚假信息中 原因，例如SSPD本身的症状可能会影响 生物测量。相比之下，一个强烈反常的发现是在 家族性SSPD受试者，在发现正常(或轻度)的情况下 精神分裂症基因贡献程度的异常发现) 在非家族性SSPD中，使生物标记物成为一个有价值的 这类调查的候选人。在这种情况下，任何虚假的 SSPD现象与生物指标的相关性研究 被排除在外。我们计划招募：家族性SSPD受试者(n=30)， 非家族性SSPD患者(n=30)、家族性SSPD患者(n=30)和非家族性SSPD患者 (n=30)无SSPD诊断的对照组。将对所有组进行匹配 社会人口学变量。家族性受试者将被招募 来自精神分裂症患者家属和非家属 来自社区的受试者。以下生物措施将是 SSPD的心理生物学评估测试和推定测试 脆弱性标记：1)将获得特定的眼球运动测量 在注视、平稳追逐和扫视任务中。转变的衡量标准 与眼球运动无关的视觉注意力也将被收集 通过波斯纳和特定的眼球跳动范例。2)其他 连续表演中持续视觉注意的测量(CPT) 将会被收取。

The studies of biological markers for genetic vulnerability to schizophrenia, which test an association between a biological measure and schizotypal symptoms, are constrained since these symptoms may lack the specificity for the schizophrenic phenotype. Although family studies of schizophrenic probands validate a familial link between schizophrenia and e schizophrenia spectrum personality (SSPD) traits, the same personality styles may or may not be related to schizophrenia when they occur in an individual who does not have a family history of schizophrenia. Environmental and other genetic factors contribute to the origins of such subtle symptoms in non-familial SSPD individuals. Therefore, an association between a biological measure and these symptoms in the non-- familial SSPD can easily be false (i.e. not related to schizophrenic vulnerability). Such an association can occur for a number of spurious reasons, for instance the symptoms of SSPD themselves may effect the biological measure. In contrast, a strongly deviant finding in the familial SSPD subjects, in the presence of a normal finding (or mildly deviant finding to the extent of the schizophrenic genetic contribution) in the nonfamilial SSPD, makes the biological marker a worthwhile candidate for such investigations. In this case, any spurious association between the phenomena of SSPD and the biological measure can be ruled out. We plan to recruit: familial SSPD subjects (n=30), non-familial SSPD subjects (n=30), and familial (n=30) and non-familial (n=30) controls with no SSPD diagnoses. All groups will be matched on socio-demographic variables. The familial subjects will be recruited from the family members of schizophrenic patients and the non-familial subjects from the community. The following biological measures will be tests to evaluate the psychobiology of SSPD and test putative vulnerability markers: 1) Specific oculomotor measures will be obtained during fixation, smooth pursuit and saccadic tasks. Measures of shift in visual attention independent of eye movements will also be collected through Posner's and specific saccadic eye movement paradigms. 2) Other measures of sustained visual attention in a continuous performance (CPT) will be collected.