FUNCTIONAL MRI STUDIES OF THE PATHOPHYSIOLOGY OF DYSLEXIA IN ADULTS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。迫切需要对阅读障碍的病理有更好的了解。这些实验的结果将提供有关发育性阅读障碍的视觉、听觉和语音异常特征的神经基质的新信息，并可能导致开发更准确的阅读障碍诊断工具。此外，我们将深度聋人纳入我们的研究，以便我们了解听觉加工对大脑中用于阅读和视觉加工的神经组织的影响及其对阅读能力的表现。在这些群体中，教学、交流和干预的作用将被研究，以研究通过获得干预前后的功能磁共振成像数据确定的教学方法的生理和行为后果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is an urgent need for an improved understanding of the pathology of dyslexia. The results of these experiments will provide new information concerning the neural substrates responsible for visual, auditory, and phonological abnormalities characteristic of developmental dyslexia and may lead to the development of more accurate diagnostic tools for dyslexia. In addition, we will include profoundly deaf individuals in our studies in order to allow us to understand the impact of auditory processing on the neural organization for reading and visual processing in the brain and its manifestation on reading ability. The role of instruction, communication and intervention will be studied in these groups in order to study the physiological as well as behavioral consequences of instructional approaches ascertained by acquiring fMRI data prior to and after intervention.