FMRI STUDIES OF THE PATHOPHYSIOLOGY OF DYSLEXIA IN CHILDREN AND ADULT

点击翻译按钮获取中文摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is an urgent need for an improved understanding of the pathology of dyslexia. The results of these experiments will provide new information concerning the neural substrates responsible for visual, auditory, and phonological abnormalities characteristic of developmental dyslexia and may lead to the development of more accurate diagnostic tools for dyslexia. Towards this goal we will also study the neurobiological basis of precocious reading - a condition seen in some children with Pervasive Developmental Disorders (PDD). In addition, we will include profoundly deaf individuals in our studies, in order to allow us to understand the impact of auditory processing on the neural organization for reading and visual processing in the brain and its manifestation on reading ability. The role of instruction, communication and intervention will be studied in these groups in order to study the physiological as well as behavioral consequences of instructional approaches, ascertained by acquiring fMRI data prior to and after intervention.