FUNCTIONAL MRI STUDIES OF COGNITION AND READING IN CHILDREN AND ADOLESCENTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 迫切需要对阅读障碍的病理学有一个更好的理解。这些实验的结果将提供有关发育性阅读障碍的视觉、听觉和语音异常的神经底物的新信息，并可能导致开发更准确的阅读障碍诊断工具。为了实现这一目标，我们还将研究早熟阅读的神经生物学基础--这是一种在一些患有普及性发育障碍(PDD)的儿童中出现的情况。此外，我们将把深度失聪的人纳入我们的研究中，以使我们能够了解听觉处理对大脑中阅读和视觉处理的神经组织的影响，以及它对阅读能力的表现。将在这些小组中研究指导、交流和干预的作用，以研究指导方法的生理和行为后果，通过获取干预前后的fMRI数据来确定。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is an urgent need for an improved understanding of the pathology of dyslexia. The results of these experiments will provide new information concerning the neural substrates responsible for visual, auditory, and phonological abnormalities characteristic of developmental dyslexia and may lead to the development of more accurate diagnostic tools for dyslexia. Towards this goal we will also study the neurobiological basis of precocious reading - a condition seen in some children with Pervasive Developmental Disorders (PDD). In addition, we will include profoundly deaf individuals in our studies, in order to allow us to understand the impact of auditory processing on the neural organization for reading and visual processing in the brain and its manifestation on reading ability. The role of instruction, communication and intervention will be studied in these groups in order to study the physiological as well as behavioral consequences of instructional approaches, ascertained by acquiring fMRI data prior to and after intervention.