CORE 3: INFRASTRUCTURE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。生物医学工程系和HIT中心成员。HIT中心明确旨在支持和促进大型跨学科和技术开发项目，如为本TCNP提议的项目。HIT中心由几个教员研究小组组成，并拥有非常先进的核心设施；因此，支持拟议项目的相当大的基础设施已经存在。我们建议在这一基础设施上增加一个计算生物学核心，以满足TCNP研究人员的特定计算需求。在计算生物学支持核心方面，Bader博士将与他在生物医学工程领域的同事Andre Levchenko博士一起，为TCNP的所有成员提供计算支持服务。这两个人都是蛋白质相互作用网络和途径的计算生物学专家。列夫琴科博士在代谢和信号通路的动态网络和定量变化建模方面拥有特殊的专业知识

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Department of Biomedical Engineering and member of the HiT Center. The HiT Center was expressly designed to support and facilitate large, interdisciplinary and technology development projects such as that proposed for this TCNP. The HiT Center consists of several faculty research groups side by side with highly advanced core facilities; thus considerable infrastructure to support the proposed project already exists. We propose to add to this infrastructure a computational biology core designed to meet the specific computational needs of the investigators in the TCNP. In the computational biology support core, Dr. Bader, together with his colleague in Biomedical Engineering, Dr. Andre Levchenko, will provide computational support services for all members of this TCNP. Both of these individuals are experts in the computational biology of protein interaction networks and pathways. Dr. Levchenko has special expertise in dynamic networks and modeling quantitative changes in metabolic and signaling pathways