Bioinformatics/Modeling/Biostatistics Core

生物信息学/建模/生物统计学核心

基本信息

  • 批准号:
    10431025
  • 负责人:
  • 金额:
    $ 12.26万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-03-16 至 2027-02-28
  • 项目状态:
    未结题

项目摘要

ABSTRACT — JHU TRAC BIOINFORMATICS, MODELING AND BIOSTATISTICS CORE (BMBC) Mycobacterium tuberculosis has evolved with humankind for centuries; as such, tuberculosis (TB) is arguably one of the most complex infectious diseases to represent analytically. From within-host processes (e.g., macrophage heterogeneity and granuloma formation) to clinical presentation (e.g., latency and a prolonged waxing-and-waning disease course) to population-level dynamics (e.g., slow epidemics driven by heterogeneous transmission and susceptibility), TB presents distinctive challenges for modeling. By the same token, however, advances in the development of computational models – including systems dynamics, statistical, and epidemiological approaches – offer an unparalleled opportunity for developing new quantitative insights into the dynamics of this uniquely human pathogen. The overall goal of the Johns Hopkins University (JHU) TRAC Bioinformatics, Modeling and Biostatistics Core (BMBC) is to ensure that innovative TB research is accelerated by access to the most recent advances in computational methods for infectious disease research. These include bioinformatics to make use of genomic, proteomic, and other high-throughput, genome-scale data; modeling, to turn these data sets into mechanistic models; and biostatistics, for expertise in applying computational methods to clinical and epidemiological research. To ensure the ability of the BMBC to achieve these goals, we have recruited leaders whose expertise spans these areas. Dr. Joel Bader, Core Director, has extensive experience in bioinformatics and modeling applied to infectious disease, as well as a long record of technology development. Co-Director Dr. David Dowdy spans mathematical modeling and epidemiology; Co-Director Dr. Aletta Nonyane has expertise in biostatistics and high-dimensional clinical data. Additional Core faculty provide deeper expertise in key content areas, including genomics, biostatistics, mechanistic modeling (within-host and population-level), systems dynamics, bioinformatics, and data science. The BMBC will achieve its overall goal and provide added value to the JHU TRAC by enabling New Investigators (NI) and Early Stage Investigators (ESI) to achieve independence in their research, whether by learning to perform computational research themselves or by establishing productive partnerships with computational counterparts. The BMBC will assist NI/ESI, as well as researchers new to the TB field, in gaining access to the high-performance computing facilities required for modern studies. Additional examples of services the BMBC will provide include partnership with NI/ESI to navigate computationally intensive components of their research, assistance with study design and/or analytical approaches relevant to specific research questions, and linkage to formal training opportunities for interested investigators. In addition, the BMBC faculty will provide synergy with the other JHU TRAC Cores and foster multi-disciplinary collaborations by participating in the weekly TRAC Seminar Series, with a focus on computational approaches to addressing critical TB knowledge gaps, as well as NI/ESI-focused Writing Accountability Groups, TRAC K-Club and K2R Club, and the annual TB Scientific Meeting and TRAC Data Fair.
JHU TRAC生物信息学、建模和生物统计学核心(BMBC) 结核分枝杆菌与人类一起进化了几个世纪;因此,结核病可以说是 分析表明,这是最复杂的传染病之一。从主机内进程(例如, 巨噬细胞异质性和肉芽肿形成)与临床表现(例如潜伏期和延长的 大起大落的疾病进程)到人口一级的动态(例如,由异质性驱动的缓慢流行 结核病的传播和易感性),给建模带来了独特的挑战。然而,出于同样的原因, 计算模型发展的进展--包括系统动力学、统计学和 流行病学方法-提供了一个无与伦比的机会,可以开发新的量化洞察 这种独特的人类病原体的动态。约翰霍普金斯大学(JHU)TRAC的总体目标 生物信息学、建模和生物统计学核心(BMBC)是确保加快创新结核病研究的核心 通过获取传染病研究的计算方法的最新进展。这些措施包括 生物信息学,利用基因组、蛋白质组和其他高通量、基因组规模的数据;建模,以 将这些数据集转化为机械模型;以及生物统计学,以获得应用计算方法的专业知识 临床和流行病学研究。为了确保BMBC有能力实现这些目标,我们有 招募了专业知识横跨这些领域的领导人。核心总监Joel Bader博士拥有丰富的经验 在生物信息学和建模方面应用于传染病,以及长期的技术发展记录。 联席主任David Dowdy博士涉及数学建模和流行病学;联席主任Aletta Nonyane博士 在生物统计学和高维临床数据方面拥有专业知识。增加核心教员提供更深层次的专业知识 在关键内容领域,包括基因组学、生物统计学、机制建模(寄主内和种群一级), 系统动力学、生物信息学和数据科学。BMBC将实现其总体目标并提供更多 通过支持新调查员(NI)和早期调查员(ESI)实现以下目标,为JHU TRAC带来价值 他们在研究中的独立性,无论是通过学习自己进行计算研究还是通过 与计算同行建立富有成效的伙伴关系。BMBC将协助NI/ESI,以及 新接触结核病领域的研究人员,在获得所需的高性能计算设施方面 现代研究。BMBC将提供的其他服务示例包括与NI/ESI合作以 导航其研究的计算密集型部分,协助研究设计和/或分析 与具体研究问题相关的方法,以及与感兴趣的正式培训机会的联系 调查人员。此外,BMBC教员将与JHU TRAC的其他核心提供协同作用,并促进 通过参加每周一次的TRAC研讨会系列,开展多学科合作,重点是 解决关键结核病知识差距的计算方法,以及以NI/ESI为重点的写作 问责制组织、TRAC K-Club和K2R Club,以及年度结核病科学会议和TRAC数据交易会。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Joel S. Bader其他文献

The de novo design and synthesis of yeast chromosome XIII facilitates investigations on aging
酵母染色体 XIII 的从头设计与合成促进了对衰老的研究
  • DOI:
    10.1038/s41467-024-54130-3
  • 发表时间:
    2024-11-22
  • 期刊:
  • 影响因子:
    15.700
  • 作者:
    Chun Zhou;Yun Wang;Yikun Huang;Yongpan An;Xian Fu;Daqian Yang;Yilin Wang;Jintao Zhang;Leslie A. Mitchell;Joel S. Bader;Yizhi Cai;Junbiao Dai;Jef D. Boeke;Zhiming Cai;Zhengwei Xie;Yue Shen;Weiren Huang
  • 通讯作者:
    Weiren Huang
Distinct Myocardial Gene Expression Signatures in Heart Failure with Preserved Ejection Fraction
  • DOI:
    10.1016/j.cardfail.2020.09.032
  • 发表时间:
    2020-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Virginia S. Hahn;Hildur Knutsdottir;Aditi Madan;Xin Luo;Kenneth Bedi;Kenneth B. Margulies;Saptarsi M. Haldar;Marina Stolina;Jun Yin;Aarif Y. Khahoo;Joban Vaishnav;Anthony Cammarato;Joel S. Bader;David A. Kass;Kavita Sharma
  • 通讯作者:
    Kavita Sharma
DNA Pooling: a tool for large-scale association studies
DNA 混合:一种用于大规模关联研究的工具
  • DOI:
    10.1038/nrg930
  • 发表时间:
    2002-11-01
  • 期刊:
  • 影响因子:
    52.000
  • 作者:
    Pak Sham;Joel S. Bader;Ian Craig;Michael O'Donovan;Michael Owen
  • 通讯作者:
    Michael Owen
Deleterious mitochondrial heteroplasmies exhibit increased longitudinal change in variant allele fraction
有害的线粒体异质性在变异等位基因分数上表现出纵向变化增加。
  • DOI:
    10.1016/j.isci.2025.112590
  • 发表时间:
    2025-06-20
  • 期刊:
  • 影响因子:
    4.100
  • 作者:
    Lieke M. Kuiper;Wen Shi;Joost A.M. Verlouw;Yun Soo Hong;Pascal Arp;Daniela Puiu;Linda Broer;Jiaqi Xie;Charles Newcomb;Stephen S. Rich;Kent D. Taylor;Jerome I. Rotter;Joel S. Bader;Eliseo Guallar;Joyce B.J. van Meurs;Dan E. Arking
  • 通讯作者:
    Dan E. Arking
Construction and iterative redesign of synXVI a 903 kb synthetic Saccharomyces cerevisiae chromosome
酿酒酵母 903kb 合成染色体 synXVI 的构建与迭代重新设计
  • DOI:
    10.1038/s41467-024-55318-3
  • 发表时间:
    2025-01-20
  • 期刊:
  • 影响因子:
    15.700
  • 作者:
    Hugh D. Goold;Heinrich Kroukamp;Paige E. Erpf;Yu Zhao;Philip Kelso;Julie Calame;John J. B. Timmins;Elizabeth L. I. Wightman;Kai Peng;Alexander C. Carpenter;Briardo Llorente;Carmen Hawthorne;Samuel Clay;Niël van Wyk;Elizabeth L. Daniel;Fergus Harrison;Felix Meier;Robert D. Willows;Yizhi Cai;Roy S. K. Walker;Xin Xu;Monica I. Espinosa;Giovanni Stracquadanio;Joel S. Bader;Leslie A. Mitchell;Jef D. Boeke;Thomas C. Williams;Ian T. Paulsen;Isak S. Pretorius
  • 通讯作者:
    Isak S. Pretorius

Joel S. Bader的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Joel S. Bader', 18)}}的其他基金

Pathway Discovery and Target Validation for Outgrowth of Breast Cancer Metastases
乳腺癌转移的途径发现和靶标验证
  • 批准号:
    10213664
  • 财政年份:
    2017
  • 资助金额:
    $ 12.26万
  • 项目类别:
A Multidisciplinary Approach to Understanding TB Latency and Reactivation
了解结核病潜伏期和再激活的多学科方法
  • 批准号:
    8052617
  • 财政年份:
    2010
  • 资助金额:
    $ 12.26万
  • 项目类别:
A Multidisciplinary Approach to Understanding TB Latency and Reactivation
了解结核病潜伏期和再激活的多学科方法
  • 批准号:
    8525429
  • 财政年份:
    2010
  • 资助金额:
    $ 12.26万
  • 项目类别:
A Multidisciplinary Approach to Understanding TB Latency and Reactivation
了解结核病潜伏期和再激活的多学科方法
  • 批准号:
    8319411
  • 财政年份:
    2010
  • 资助金额:
    $ 12.26万
  • 项目类别:
Genetic Hotspots for Disease Risk
疾病风险的遗传热点
  • 批准号:
    7908317
  • 财政年份:
    2010
  • 资助金额:
    $ 12.26万
  • 项目类别:
A Multidisciplinary Approach to Understanding TB Latency and Reactivation
了解结核病潜伏期和再激活的多学科方法
  • 批准号:
    8145243
  • 财政年份:
    2010
  • 资助金额:
    $ 12.26万
  • 项目类别:
CORE 3: INFRASTRUCTURE
核心 3:基础设施
  • 批准号:
    7724694
  • 财政年份:
    2008
  • 资助金额:
    $ 12.26万
  • 项目类别:
CORE 3: INFRASTRUCTURE
核心 3:基础设施
  • 批准号:
    7622848
  • 财政年份:
    2007
  • 资助金额:
    $ 12.26万
  • 项目类别:
Structural, Functional & Evolutionary Genomics Gordon Conference
结构性、功能性
  • 批准号:
    7273912
  • 财政年份:
    2007
  • 资助金额:
    $ 12.26万
  • 项目类别:
CORE 3: INFRASTRUCTURE
核心 3:基础设施
  • 批准号:
    7380819
  • 财政年份:
    2006
  • 资助金额:
    $ 12.26万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 12.26万
  • 项目类别:
    Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 12.26万
  • 项目类别:
    Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 12.26万
  • 项目类别:
    Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 12.26万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 12.26万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 12.26万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 12.26万
  • 项目类别:
    EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 12.26万
  • 项目类别:
    Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 12.26万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 12.26万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了