Structural, Functional & Evolutionary Genomics Gordon Conference

结构性、功能性

• 批准号: 7273912
• 负责人: Joel S. Bader
• 金额: $ 1.7万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-08 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7273912
• 关键词: Algorithms; Animal Model; Architecture; Asia; Biodiversity; Bioinformatics; Biological; Canada; Code; Complex; DNA; Data; Data Set; Europe; Evolution; Functional RNA; Funding; Gene Expression; Gene Expression Regulation; Gene Proteins; Genome; Genomics; Goals; Human; Human Biology; Institutes; Life; Methods; Minority; Noise; Proteins; Proteome; Request for Proposals; Research; Scientist; Senior Scientist; Site; System; Systems Biology; Technology; Trust; Woman; career; comparative; functional genomics; human disease; protein function; symposium; theories; trait

DESCRIPTION (provided by applicant): This proposal requests funds to support the Gordon Research Conference on Structural, Functional & Evolutionary Genomics, July 29 - August 3, 2007, at the Wellcome Trust Sanger Institute Genome Center in Hinxton, UK, and for the subsequent meeting in 2009. The GRC on Structural, Functional & Evolutionary Genomics is devoted to ambitious analysis of biological systems at the broadest scale possible: full genomes and proteomes; full examination of gene and protein function in the context of biological networks; and full use of the power of comparative genomics and evolutionary theory. This GRC is unique in bringing together experts in both the experimental and computational / theoretical aspects of this research. Experimental talks introduce computational scientists to new, promising data sets and empirical results. Computational talks provide experimentalists with new methods and algorithms for revealing the significance of their findings and also offer the theoretical framework that is needed to integrate different types of data. The broad themes for the 2007 meeting are the evolution of gene regulation, non-protein-coding DNA, and regulatory networks; evolution of networks in the presence of noise; comparative genomics of gene expression; biodiversity and metagenomics; functional genomics; evolution of synthetic life; and contribution of comparative genomics to our understanding of the major transitions in life's evolution. The topics discussed in the meeting have broad relevance to understanding basic human biology. Specific topics including the function of non-coding DNA and the genomic architecture of complex traits are directly relevant to human disease, especially as technologies first developed for model organisms are applied to human. In addition to the scientific objectives, this GRC, in line with the broad goals of Gordon Conferences, strives to encourage mixing and interactions among a diverse scientific body. We aim to have representation from senior scientists and those just starting their scientific careers and to include, as much as possible, women and minorities. The GRC has an additional goal of encouraging scientific interchange between the US and Canada, Europe, Asia, and other scientific centers. In that regard, this GRC stands a chance to be particularly fruitful because it will be the first meeting at a new GRC site, Hinxton (UK), a major center of Genomics, Systems Biology, and Bioinformatics for the UK and Europe.

描述（由申请人提供）：该提案要求资金支持戈登的结构，功能和进化基因组学研究会议，2007年7月29日至2007年8月3日，在英国欣克斯顿的惠康信托基金会基因组中心，在2009年进行的范围内分析。基因组和蛋白质组；在生物网络的背景下对基因和蛋白质功能进行全面检查；并充分利用比较基因组学和进化论的力量。该GRC在将本研究的实验和计算 /理论方面汇集在一起​​时是独一无二的。实验谈判将计算科学家介绍了新的，有希望的数据集和经验结果。计算谈判为实验者提供了新的方法和算法，以揭示其发现的重要性，还提供了整合不同类型数据所需的理论框架。 2007年会议的广泛主题是基因调节，非蛋白质编码DNA和调节网络的演变。在存在噪声的情况下网络的演变；基因表达的比较基因组学；生物多样性和宏基因组学；功能基因组学；综合生活的演变；比较基因组学对我们对生活进化中主要过渡的理解的贡献。会议中讨论的主题与理解基本人类生物学具有广泛的相关性。具体主题，包括非编码DNA的功能和复杂性状的基因组结构与人类疾病直接相关，尤其是当最初针对模型生物开发的技术被应用于人类时。 除了科学目标外，该GRC还符合戈登会议的广泛目标，还努力鼓励在多样化的科学机构之间进行混合和互动。我们的目标是要与高级科学家以及刚刚开始科学事业的人的代表，并尽可能多地包括妇女和少数民族。 GRC具有鼓励美国，加拿大，欧洲，亚洲和其他科学中心之间的科学互换的其他目标。在这方面，此GRC有一个特别富有成果的机会，因为它将是新的GRC网站，英国Hinxton（英国）的首次会议，这是英国和欧洲的基因组学，系统生物学和生物信息学的主要中心。