Structural, Functional & Evolutionary Genomics Gordon Conference

描述（由申请人提供）：本提案要求提供资金，以支持2007年7月29日至8月3日在英国Hinxton的Wellcome Trust桑格研究所基因组中心举行的结构、功能和进化基因组学戈登研究会议，以及2009年的后续会议。结构，功能和进化基因组学的GRC致力于在尽可能广泛的范围内对生物系统进行雄心勃勃的分析：完整的基因组和蛋白质组;在生物网络的背景下对基因和蛋白质功能进行全面检查;以及充分利用比较基因组学和进化理论的力量。这个GRC是独一无二的，它汇集了这项研究的实验和计算/理论方面的专家。实验讲座向计算科学家介绍了新的，有前途的数据集和经验结果。计算讲座为实验者提供了新的方法和算法，以揭示他们发现的重要性，并提供了整合不同类型数据所需的理论框架。 2007年会议的广泛主题是基因调控，非蛋白质编码DNA和调控网络的演变;噪音存在下的网络演变;基因表达的比较基因组学;生物多样性和宏基因组学;功能基因组学;合成生命的演变;以及比较基因组学对我们理解生命进化中主要转变的贡献。会议讨论的主题与理解基本的人类生物学具有广泛的相关性。包括非编码DNA的功能和复杂性状的基因组结构在内的特定主题与人类疾病直接相关，特别是当最初为模式生物开发的技术应用于人类时。 除了科学目标外，该GRC还符合戈登会议的广泛目标，努力鼓励多元化科学机构之间的混合和互动。我们的目标是让资深科学家和刚刚开始科学生涯的科学家代表参加，并尽可能包括妇女和少数民族。GRC的另一个目标是鼓励美国和加拿大，欧洲，亚洲和其他科学中心之间的科学交流。在这方面，这个GRC站在一个特别富有成效的机会，因为它将是在一个新的GRC网站，Hinxton（英国），一个主要的基因组学，系统生物学和生物信息学中心为英国和欧洲的第一次会议。

DESCRIPTION (provided by applicant): This proposal requests funds to support the Gordon Research Conference on Structural, Functional & Evolutionary Genomics, July 29 - August 3, 2007, at the Wellcome Trust Sanger Institute Genome Center in Hinxton, UK, and for the subsequent meeting in 2009. The GRC on Structural, Functional & Evolutionary Genomics is devoted to ambitious analysis of biological systems at the broadest scale possible: full genomes and proteomes; full examination of gene and protein function in the context of biological networks; and full use of the power of comparative genomics and evolutionary theory. This GRC is unique in bringing together experts in both the experimental and computational / theoretical aspects of this research. Experimental talks introduce computational scientists to new, promising data sets and empirical results. Computational talks provide experimentalists with new methods and algorithms for revealing the significance of their findings and also offer the theoretical framework that is needed to integrate different types of data. The broad themes for the 2007 meeting are the evolution of gene regulation, non-protein-coding DNA, and regulatory networks; evolution of networks in the presence of noise; comparative genomics of gene expression; biodiversity and metagenomics; functional genomics; evolution of synthetic life; and contribution of comparative genomics to our understanding of the major transitions in life's evolution. The topics discussed in the meeting have broad relevance to understanding basic human biology. Specific topics including the function of non-coding DNA and the genomic architecture of complex traits are directly relevant to human disease, especially as technologies first developed for model organisms are applied to human. In addition to the scientific objectives, this GRC, in line with the broad goals of Gordon Conferences, strives to encourage mixing and interactions among a diverse scientific body. We aim to have representation from senior scientists and those just starting their scientific careers and to include, as much as possible, women and minorities. The GRC has an additional goal of encouraging scientific interchange between the US and Canada, Europe, Asia, and other scientific centers. In that regard, this GRC stands a chance to be particularly fruitful because it will be the first meeting at a new GRC site, Hinxton (UK), a major center of Genomics, Systems Biology, and Bioinformatics for the UK and Europe.