COBRE: UVM: CORE D: TRANSLATIONAL NEUROSCIENCE TRAINING

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This Core is in its 4th year of support, with the goal to provide an intellectual environment encouraging career development in translational neuroscience. Previously, the core had provided the stipend to support a research fellowship for two medical students (Coates and Kelley) who conducted full-time bench research with Drs. Mawe and Wellman. Mr. Coates¿ published one paper and presented at national meetings. This success motivated Mr. Coates to enter UVM¿s MD/PhD program. Mr. Kelley has graduated and is currently a resident at the University of North Carolina. During the year the core provided additional fellowship support for two medical students (Ciolino and Quick). These students have conducted research with Drs. Mawe and Cipolla. Ms. Quick's work has resulted in one published paper and Ms. Ciolino is continuing her fellowship. This year, Ms. Chuan-Ju Pan is conducting research in Dr. Eckenstein's laboratory, and it is expected that she will co-author two publications. Additionally, this year Dr. Meagan Costedio is conducting research in Dr. Gary Mawe's lab. Her research consists of a project to determine if serotonin concentrations and signaling are altered in the colons of people with diverticulosis, and how they compare with colons of people with diverticulitis. A course illustrating the progress of translational neuroscience research has been organized. The course provides an in-depth analysis of research into a single neurological disease. The disease to be covered changes every year. Past disease entities covered include Parkinson's Disease, Multiple Sclerosis and Schizophrenia. This year's course will focus on Amyotrophic Lateral Sclerosis. The course consists of 12 weekly sessions ranging from clinical research to basic molecular approaches. Faculty from the Departments of Neurology, Neurosurgery, Psychology, Medicine and Anatomy & Neurobiology collaborate in this team-taught course. In addition, two outside speakers contributed lectures this year. An Undergraduate Neuroscience Summer fellowship program has been established. Undergraduates perform 10 weeks of research, read primary literature and attend lectures given by COBRE faculty. Approximately 40 students (most from institutions different from UVM) apply, and approximately 8 are selected. Several have gone on to Ph.D. graduate programs.