UDALL PARKINSON?S DISEASE CENTER AT EMORY UNIVERSITY: CIRCUITRY TO THERAPY

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 最近获得资助的Morris K.埃默里大学的Udall帕金森病卓越中心是一个高度合作的研究项目，其中电生理学家，药理学家和解剖学家共同研究从电路角度对帕金森症的现有和新治疗方法的影响。该中心由四个项目和两个核心组成。项目1（Jaeger博士）研究帕金森病状态下基底神经节输入改变对丘脑神经元的影响。项目2（Wichmann博士）是在帕金森病灵长类动物中进行的一系列实验，目的是比较苍白球和丘脑底核失活和刺激的丘脑效应，这通常用于治疗晚期帕金森病患者，目的是确定与这些程序的抗帕金森病效应相关的丘脑活动变化。项目3（米勒博士）是一系列转化实验，在不同的啮齿动物和灵长类动物模型中研究口服活性TrkB受体激动剂作为帕金森病的对症或神经恢复治疗的用途。项目4（Dr. Conn，范德比尔特）研究了新型亚型选择性毒蕈碱乙酰胆碱受体拮抗剂和激活剂对基底神经节活性的影响，以及对啮齿动物模型中帕金森症的影响。这些项目由一个管理核心（核心A，Dr. Wichmann，PI; Dr. DeLong，Co-I，Dr. Pearson，管理员）和一个解剖学和行为核心（核心B，Dr. Smith）支持，该核心为所有中心项目提供免疫组织化学和电子显微镜服务，并在项目3下对MPTP处理的猴进行行为测试。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The recently funded Morris K. Udall Parkinson's Disease Center of Excellence at Emory University is a highly collaborative research program in which electrophysiologists, pharmacologists, and anatomists work together to study the effects of existing and new treatments for parkinsonism from a circuit perspective. The center consists of four projects and two cores. Project 1 (Dr. Jaeger) examines changes imposed by altered basal ganglia input onto thalamic neurons in the parkinsonian state. Project 2 (Dr. Wichmann) is a series of experiments in parkinsonian primates to compare the thalamic effects of pallidal and subthalamic nucleus inactivation and stimulation, as are commonly used to treat advanced parkinsonism in patients, with the goal of identifying changes in thalamic activity that are associated with the antiparkinsonian effects of these procedures. Project 3 (Dr. Miller) is a series of translational experiments that examine the use of orally active TrkB receptor agonists as symptomatic or neurorestorative treatment for Parkinson's disease in different rodent and primate models. Project 4 (Dr. Conn, Vanderbilt) investigates the effects of novel subtype-selective muscarinic acetylcholine receptor antagonists and activators on basal ganglia activity, and on parkinsonism in rodent models. The projects are supported by an administrative core (Core A, Dr. Wichmann, PI; Dr. DeLong, Co-I, Dr. Pearson, administrator), and by an anatomy and behavior core (Core B, Dr. Smith) which provides immunohistochemistry and electron microscopy services to all of the center projects, and conducts behavioral testing in MPTP-treated monkeys under project 3.