COBRE: UVM: CORE D: TRANSLATIONAL NEUROSCIENCE TRAINING

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This Core is in its 5th year of support, with the goal to provide an environment encouraging career development in translational neuroscience. Previously, the core had provided the stipend to support an annual research fellowship for medical students (Mr. Coates, Mr. Kelley, Ms. Ciolino, Ms. Quick and Ms. Pan) who conducted full-time bench research with Drs. Mawe, Wellman, Mawe, Cipolla and Eckenstein, respectively. Mr. Coates published one paper and presented at national meetings. This success motivated Mr. Coates to enter UVMs MD/PhD program. He has successfully completed his PhD training and MD. Mr. Kelley has graduated and is currently a resident at the University of North Carolina. Ms. Quick's work has resulted in one published paper and Ms. Ciolino is a Resident in Pathology at UVM. Last year, Ms. Pan was conducting research in Dr. Eckenstein's laboratory, one publication has been submitted and she is expected to co-author another publication. A course illustrating the progress of translational neuroscience research has been organized. The course provides an in-depth analysis of research into a single neurological disease. The disease to be covered changes every year. Past disease entities covered include Parkinson's Disease, Multiple Sclerosis, Schizophrenia and Amyotrophic Lateral Sclerosis. Next year's course will focus on Cerebrovascular diseases. The course consists of 12 weekly sessions ranging from clinical research to basic molecular approaches. Faculty from the Departments of Neurology, Neurosurgery, Psychology, Medicine and Anatomy & Neurobiology collaborate in this team-taught course. In addition, four outside speakers contributed lectures this year (Drs. Robert Brown, Harvard University; Jeffrey Rothstein, Johns Hopkins University, Jeremy Shefner, SUNY upstate, and JoAnne St. Pierre, ALS association). An Undergraduate Neuroscience Summer fellowship program has been established. Undergraduates perform 10 weeks of research, read primary literature and attend lectures given by COBRE faculty. This year over 80 students (most from institutions different from UVM) apply, and 8 were accepted. Several of our past students have gone on to Ph.D. graduate programs, including two who have joined our Neurosciences program.