COBRE: MECHANISMS OF PLASTICITY & REPAIR AFTER SCI D: BEHAV & ELECTROPHYS CORE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。电生理和行为核心（CORE D）的目的是提供一系列标准测试，以评估动物及其脊髓在受伤和治疗后的功能，并促进COBRE项目可能需要的更专业测试的开发。CORE将提供以下测试：经颅磁运动诱发电位（tcMMEPs）评估大鼠和小鼠腹外侧索下行轴突的动作电位传导。2. 躯体感觉诱发电位（ssep）评估上行初级感觉通路（仅限大鼠）。3. 磁扩间反射（MIERs）评估位于外侧白质的上升本体脊髓轴突的传导（仅限大鼠）。4. 空地运动量表（BBB）评估大鼠在地上运动时的后肢功能；Basso小鼠量表（BMS）评估小鼠在地上运动时的后肢功能。5. 栅格行走试验评估感觉运动功能。6. 采用路易斯维尔游泳量表（LSS，仅限大鼠）评估游泳时后肢功能。7. 以关节角度、肢体偏移和步循环时间为主要测量指标的大鼠和小鼠在地上运动和游泳时的后肢运动学。8. 哈格里夫试验评估皮肤痛觉过敏。9. 电弗雷毛发评估损伤后的机械超敏反应。此外，CORE将根据COBRE实验室内具体项目的需要，开发新的电生理和行为评估工具。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the Electrophysiology and Behavior CORE (CORE D) is to provide a battery of standard tests to assess the function of animals and their spinal cords after injury and treatment, and to facilitate the development of more specialized tests that may be needed for the COBRE projects. The CORE will provide the following tests: 1. Transcranial magnetic motor evoked potentials (tcMMEPs) to assess action potential conduction in descending axons located in the ventrolateral funiculus in rats and mice. 2. Somatosensory evoked potentials (SSEPs) to assess ascending primary sensory pathways (rats only). 3. Magnetic interenlargement reflexes (MIERs) to assess conduction in ascending propriospinal axons located in the lateral white matter (rats only). 4. Open Field Locomotor Scale (BBB) to assess hindlimb function during overground locomotioin in rats and the Basso Mouse Scale (BMS) for mice. 5. A grid-walking test to assess sensorimotor function. 6. The Louisville Swimming Scale (LSS; rats only) to assess hindlimb function during swimming. 7. Hindlimb kinematics during overground locomotion and swimming for rats and mice using joint angle, limb excursion and step cycle duration as primary measures. 8. The Hargreave's test to assess cutaneous hyperalgesia. 9. Electro von Frey hairs to assess mechano-hypersensitivity after injury. In addition the CORE will pursue the development of novel electrophysiological and behavioral assessment tools as needed by specific projects within the COBRE laboratires.