COBRE: MECHANISMS OF PLASTICITY & REPAIR AFTER SCI D: BEHAV & ELECTROPHYS CORE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 电生理和行为核心(核心D)的目的是提供一系列标准测试，以评估动物及其脊髓在受伤和治疗后的功能，并促进开发科布雷项目可能需要的更专门的测试。核心将提供以下测试：1.经颅磁运动诱发电位(TcMMEPs)，以评估大鼠和小鼠腹外侧索内下行轴突的动作电位传导。2.体感诱发电位(SSEP)用于评估上行初级感觉通路(仅限大鼠)。3.磁中间扩大反射(MIERS)用于评估位于白质外侧的上升固有脊髓轴突的传导(仅限大鼠)。4.用开放式田野运动评定量表(BBB)评定大鼠在地面运动时的后肢功能，用Basso小鼠评定量表(BMS)评定小鼠的后肢功能。5.用于评估感觉运动功能的栅格行走试验。6.路易斯维尔游泳量表(LSS；仅限大鼠)，用于评估游泳过程中的后肢功能。7.以关节角度、肢体偏移量和步幅为主要指标，研究大鼠和小鼠在地面运动和游泳过程中的后肢运动学。8.评估皮肤痛觉过敏的Hargreave‘s试验。9.电von Frey毛发用于评估损伤后的机械超敏反应。此外，根据科布雷实验室内具体项目的需要，该中心将致力于开发新的电生理和行为评估工具。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the Electrophysiology and Behavior CORE (CORE D) is to provide a battery of standard tests to assess the function of animals and their spinal cords after injury and treatment, and to facilitate the development of more specialized tests that may be needed for the COBRE projects. The CORE will provide the following tests: 1. Transcranial magnetic motor evoked potentials (tcMMEPs) to assess action potential conduction in descending axons located in the ventrolateral funiculus in rats and mice. 2. Somatosensory evoked potentials (SSEPs) to assess ascending primary sensory pathways (rats only). 3. Magnetic interenlargement reflexes (MIERs) to assess conduction in ascending propriospinal axons located in the lateral white matter (rats only). 4. Open Field Locomotor Scale (BBB) to assess hindlimb function during overground locomotioin in rats and the Basso Mouse Scale (BMS) for mice. 5. A grid-walking test to assess sensorimotor function. 6. The Louisville Swimming Scale (LSS; rats only) to assess hindlimb function during swimming. 7. Hindlimb kinematics during overground locomotion and swimming for rats and mice using joint angle, limb excursion and step cycle duration as primary measures. 8. The Hargreave's test to assess cutaneous hyperalgesia. 9. Electro von Frey hairs to assess mechano-hypersensitivity after injury. In addition the CORE will pursue the development of novel electrophysiological and behavioral assessment tools as needed by specific projects within the COBRE laboratires.