COBRE: UL: MECHANISMS OF PLASTICITY AND REPAIR AFTER SCI/ C: SURGICAL CORE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。核心C的目的将是通过提供可重复执行其手术和兽医护理程序所需的专业知识、人员、设施、设备和用品，显著减少提案中所有项目的可变性。标准化的手术程序将包括造成成年大鼠和小鼠脊髓损伤的挫伤和撕裂伤加上细胞移植、注射、神经解剖示踪、颅骨电极植入、安乐死、灌流固定和组织解剖。标准化的日常兽医护理程序旨在显著降低发病率和死亡率。这些措施将包括治疗伤口、排出膀胱、预防尿路和其他感染，以及提供补充液体和营养。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of Core C will be to significantly reduce variability in all Projects of the proposal by providing the expertise, personnel, facilities, equipment, and supplies required to reproducibly perform their surgery and veterinary care procedures. The standardized surgery procedures will include producing contusion and laceration types of spinal cord cord injuries in adult rats and mice plus cell transplantation, injection, neuroanatomical tracing, cranial electrode implantation, euthanasia, perfusion fixation, and tissue dissection. The standardized, daily veterinary care procedures are designed to significantly reduce morbidity and mortality. They will include treating wounds, expressing bladders, preventing urinary tract and other infections, plus providing supplemental fluids and nutrition.