COBRE: MECHANISMS OF PLASTICITY & REPAIR AFTER SCI D: BEHAV & ELECTROPHYS CORE

COBRE：可塑性机制

• 批准号: 7720375
• 负责人: David SK Magnuson
• 金额: $ 18.69万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720375
• 关键词: Action Potentials; Animals; Axon; Behavior; Behavior assessment; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Development; Electrophysiology (science); Funding; Grant; Hair; Hindlimb; Hypersensitivity; Injury; Institution; Joints; Lateral; Limb structure; Locomotion; Magnetism; Measures; Motor Evoked Potentials; Mus; Pathway interactions; Purpose; Rattus; Reflex action; Research; Research Personnel; Resources; Sensorimotor functions; Sensory; Somatosensory Evoked Potentials; Source; Spinal Cord; Standards of Weights and Measures; Swimming; Testing; Thermal Hyperalgesias; United States National Institutes of Health; Walking; kinematics; novel; repaired; tool; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the Electrophysiology and Behavior CORE (CORE D) is to provide a battery of standard tests to assess the function of animals and their spinal cords after injury and treatment, and to facilitate the development of more specialized tests that may be needed for the COBRE projects. The CORE will provide the following tests: 1. Transcranial magnetic motor evoked potentials (tcMMEPs) to assess action potential conduction in descending axons located in the ventrolateral funiculus in rats and mice. 2. Somatosensory evoked potentials (SSEPs) to assess ascending primary sensory pathways (rats only). 3. Magnetic interenlargement reflexes (MIERs) to assess conduction in ascending propriospinal axons located in the lateral white matter (rats only). 4. Open Field Locomotor Scale (BBB) to assess hindlimb function during overground locomotioin in rats and the Basso Mouse Scale (BMS) for mice. 5. Grid-walking test and horizontal ladder tests to assess sensorimotor function. 6. The Louisville Swimming Scale (LSS; rats only) to assess hindlimb function during swimming. 7. Hindlimb kinematics during overground locomotion and swimming for rats and mice using joint angle, limb excursion and step cycle duration as primary measures. 8. The Hargreave's test to assess thermal hyperalgesia. 9. Electro von Frey hairs to assess mechano-hypersensitivity after injury. In addition the CORE will pursue the development of novel electrophysiological and behavioral assessment tools as needed by specific projects within the COBRE laboratires.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 电生理学和行为核心（CORE D）的目的是提供一系列标准测试，以评估动物及其脊髓在损伤和治疗后的功能，并促进COBRE项目可能需要的更专业测试的开发。 CORE将提供以下测试：1.经颅磁运动诱发电位（tcMMEPs）评估大鼠和小鼠腹外侧索下行轴突的动作电位传导。 2.体感诱发电位（SSEP），用于评估上行初级感觉通路（仅大鼠）。3.磁髓间反射（MIER），以评估位于外侧白色物质（仅大鼠）中的上行脊髓本体轴突的传导。4.在大鼠中采用旷场运动量表（BBB）评估地上运动期间的后肢功能，在小鼠中采用Basso小鼠量表（BMS）评估。5.网格行走试验和水平梯试验评估感觉运动功能。6. Louisville游泳量表（LSS;仅大鼠）评估游泳期间的后肢功能。7.大鼠和小鼠在地上运动和游泳过程中的后肢运动学，使用关节角度、肢体偏移和步周期持续时间作为主要测量。8.哈氏试验评估热痛觉过敏。9.电von Frey毛发以评估损伤后的机械超敏反应。 此外，核心将根据COBRE实验室内特定项目的需要开发新型电生理和行为评估工具。