LBRN: BIOINFORMATICS BIOCOMPUTING CORE

LBRN：生物信息学生物计算核心

• 批准号: 7381322
• 负责人: EDWARD R SEIDEL
• 金额: $ 27.27万
• 依托单位: LOUISIANA STATE UNIV A&M COL BATON ROUGE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381322
• 关键词: LBRN; BIOINFORMATICS; BIOCOMPUTING; CORE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Rationale and Specific Aims: According to the NIH Biomedical Information Science and Technology Initiative Consortium (NIH-BISTI) "Bioinformatics is research, development, or application of computational tools and approaches for expanding the use of biological, medical, behavioral or health data, including those to acquire, store, organize, archive, analyze, or visualize such data" (http://www.bisti.nih.gov). The rapid growth of biological information has necessitated the development and implementation of advanced biocomputing and bioinformatics resources and capabilities, which are currently deemed essential components for biomedical research. Typically, these resources are optimally used when an efficient user-friendly and shared networking system is in place. The elucidation of the human and other genomes has provided an immense amount of data that must be analyzed by computationally intensive methods launching the era of genomics. Similarly, understanding the proteins coded by individual genomes, their regulated expression, structure, function and interaction (proteomics), will require the development of new hardware and software beyond current capabilities. Some important areas that will greatly impact biomedical research are: advanced visualization; data mining; distributed and shared analysis and storage of large data sets; dynamic simulation and modeling of biological processes. The Bioinformatics/Biocomputing Core (BBC) focuses on providing the necessary networking capabilities to support biomedical research projects distributed throughout the state of Louisiana. It is envisioned that the initial BBC's efforts in biocomputing/bioinformatics will demonstrate competitive research in Louisiana, which will grow as the network expands and faculty are added. A primary goal of the BBC is to provide access to world-class computer resources and computing, and communication support for the entire INBRE. Of particular importance is providing a supportive environment for the specific research projects associated with this core, as well as projects in the MCBC. In addition, the BBC will develop and distribute new biocomputational capabilities to enable competitive research by all INBRE institutions. The BBC includes an initial cadre of pilot projects aimed at achieving this goal. It is anticipated that additional biocomputational projects will be developed during the INBRE as new faculty are hired and the network grows. The BBC will be built upon the existing resources of the Center for Computation and Technology (CCT, see description below) on the LSU campus, the LBRN Phase I resources, including those at the LSU Eye Center (LSUEC), and those being built under the auspices of LONI. The BBC will foster enhanced training of undergraduate and graduate students, as well as faculty, by initiating novel methods of delivering expertise across campus boundaries. This training and interaction will provide: networked courses; access to seminars and workshops; remote access to research equipment; person-to-person teleconferencing; other forms of distance learning, communication and collaboration. We consider these elements as absolutely essential to the enhancement of biomedical research since it promotes the development of state-wide mentoring at all educational levels. The specific aims of the BBC are: Specific Aim I: To support and further develop the existing Access-Grid and high speed networking infrastructure. The goal is to facilitate interactive knowledge and data exchange among INBRE investigators, further enhancing interdisciplinary collaboration. Specific Aim II: To support an initial cadre of investigators who will develop research projects that utilize advanced biocomputation methodologies. Specific Aim III: To provide communication and network support for the development of training and research programs at PUI campuses, including undergraduate, graduate, post-doctoral fellows, and faculty. The intended goal is to provide state-of-the-art resources, mentoring, and research experiences, beyond the boundaries of home departments and institutions.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。理由和具体目标：根据NIH生物医学信息科学和技术倡议联盟（NIH-BISTI）的说法，“生物信息学是研究、开发或应用计算工具和方法，以扩大生物、医学、行为或健康数据的使用，包括获取、存储、组织、存档、分析或可视化这些数据”（http：www.bisti.nih.gov）。生物信息的迅速增长要求开发和实施先进的生物计算和生物信息学资源和能力，这是目前生物医学研究的基本组成部分。通常，当一个有效的用户友好和共享的网络系统到位时，这些资源得到最佳利用。人类和其他基因组的阐明提供了大量的数据，这些数据必须通过计算密集型方法进行分析，从而开启了基因组学时代。同样，要了解由单个基因组编码的蛋白质、其受调控的表达、结构、功能和相互作用（蛋白质组学），就需要开发超出现有能力的新硬件和软件。将对生物医学研究产生重大影响的一些重要领域是：先进的可视化;数据挖掘;大型数据集的分布式和共享分析和存储;生物过程的动态模拟和建模。 生物信息学/生物计算核心（BBC）的重点是提供必要的网络能力，以支持分布在路易斯安那州的生物医学研究项目。据设想，最初的BBC在生物计算/生物信息学方面的努力将在路易斯安那州展示有竞争力的研究，随着网络的扩大和教师的增加，这将不断增长。BBC的主要目标是为整个INBRE提供世界级的计算机资源和计算以及通信支持。特别重要的是，为与这一核心有关的具体研究项目以及《气候变化框架公约》中的项目提供一个支持性环境。此外，英国广播公司将开发和分发新的生物计算能力，以使所有INBRE机构的研究具有竞争力。英国广播公司包括一个旨在实现这一目标的试点项目的初步骨干。预计在INBRE期间，随着新教师的聘用和网络的发展，将开发更多的生物计算项目。 BBC将建立在计算和技术中心（CCT，见下文描述）的现有资源上，LBRN第一阶段的资源，包括LSU眼科中心（LSUEC）的资源，以及在LONI主持下建造的资源。英国广播公司将促进加强本科生和研究生的培训，以及教师，通过启动跨校园边界提供专业知识的新方法。这种培训和互动将提供：网络课程;参加研讨会和讲习班;远程使用研究设备;个人对个人的远程会议;其他形式的远程学习、交流和协作。我们认为这些因素对于加强生物医学研究是绝对必要的，因为它促进了全州范围内各级教育指导的发展。BBC的具体目标是：具体目标一：支持和进一步发展现有的物联网网格和高速网络基础设施。目标是促进国家建筑研究所调查人员之间的互动式知识和数据交流，进一步加强跨学科合作。 具体目标二：支持一批初步的研究人员，他们将开发利用先进生物计算方法的研究项目。 具体目标三：为PUI校园的培训和研究计划的发展提供通信和网络支持，包括本科生，研究生，博士后研究员和教师。预期的目标是提供最先进的资源，指导和研究经验，超越家庭部门和机构的界限。