Delaware INBRE

特拉华州INBRE

• 批准号: 7925092
• 负责人: DAVID S WEIR
• 金额: $ 4.04万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7925092
• 关键词: Address; American; Area; Biocompatible Materials; Bioinformatics; Biomedical Research; Breast; Cardiac; Cardiovascular system; Cell Mobility; Clinical Research; Communities; Cytoskeleton; DNA Repair; Data; Delaware; Development; Diabetes Mellitus; Disease; Faculty; Foundations; Funding; Future; Generations; Goals; Grant; Health; Healthcare; Healthcare Industry; Heart Diseases; Heart failure; Image; Institution; Knowledge; Lead; Learning; Life; Malignant Neoplasms; Mammography; Memory; Methods; Molecular; Neoplasm Metastasis; Neurosciences; Optics; Pilot Projects; Proteins; Research; Research Infrastructure; Research Personnel; Research Project Grants; Role; Scientist; Seeds; Spinal Muscular Atrophy; Students; Surface; Tissue Engineering; Work; autonomic nerve; base; breast density; cancer cell; cancer therapy; career; college; design; graduate student; improved; instrumentation; lifetime risk; malignant breast neoplasm; programs; public health relevance; reconstruction

DESCRIPTION (provided by applicant): The goal of the Delaware INBRE renewal proposal is to take another major step towards improving health care in the State by extending the work of the current INBRE in building a statewide biomedical research capability. The project will continue to strengthen the research expertise and infrastructure of the lead and partner institutions. Three research themes will be pursued. A cancer program, begun under the current INBRE, will focus on cancer cell mobility, the role of specific proteins in metastasis, DNA repair and biomaterials for use in cancer treatments. A new cardiovascular program will focus on extra-cellular matrix remodeling in heart failure and biomaterials for cardiac tissue engineering. A new neuroscience program will address molecular mechanisms of learning and memory, spinal muscular atrophy and cardiovascular autonomic nerve function in diabetes. Funds to support junior faculty, postdoctoral and graduate students engaged in the research projects within each research theme, are provided. The Research Themes are supported by a statewide biomedical infrastructure developed under the current INBRE, but with considerably enhanced Bioinformatics and Centralized Instrumentation Cores. An Undergraduate Research and Professional Development Core will provide research opportunities for students from the State's undergraduate institutions and community colleges, thereby developing a pipeline of students pursuing careers in the health care industry and enhancing the technical knowledge of the State's workforce. PUBLIC HEALTH RELEVANCE (provided by applicant): The Delaware INBRE is focused on research in cancer, heart disease and neuroscience, three areas where disease take the lives of millions of Americans each year. The project helps promising scientists to begin their research careers/by providing research seed grants, which form a foundation for future research. Delaware INBRE also helps to build a new generation of health researchers, by involving undergraduate

描述（由申请人提供）：特拉华州 INBRE 更新提案的目标是通过扩展当前 INBRE 在建立全州生物医学研究能力方面的工作，向改善该州的医疗保健迈出又一重大步骤。该项目将继续加强牵头机构和合作机构的研究专业知识和基础设施。将开展三个研究主题。在当前的 INBRE 下启动的一项癌症计划将重点关注癌细胞移动性、特定蛋白质在转移中的作用、DNA 修复以及用于癌症治疗的生物材料。一项新的心血管项目将重点关注心力衰竭的细胞外基质重塑和心脏组织工程的生物材料。一项新的神经科学项目将研究糖尿病中学习和记忆、脊髓性肌萎缩和心血管自主神经功能的分子机制。提供资金支持从事每个研究主题内的研究项目的初级教师、博士后和研究生。研究主题得到了当前 INBRE 下开发的全州生物医学基础设施的支持，但生物信息学和集中仪器核心得到了显着增强。本科生研究和专业发展核心将为来自纽约州本科院校和社区学院的学生提供研究机会，从而培养一批在医疗保健行业谋求职业生涯的学生，并提高纽约州劳动力的技术知识。 公共卫生相关性（由申请人提供）：特拉华州 IBRE 专注于癌症、心脏病和神经科学的研究，这三个领域的疾病每年夺去数百万美国人的生命。该项目通过提供研究种子资助来帮助有前途的科学家开始他们的研究生涯，为未来的研究奠定基础。特拉华州 INBRE 还通过让本科生参与来帮助培养新一代健康研究人员