INTERSPECIES COMMUNICATION BETWEEN THE HUMAN DENTAL PLAQUE BACTERIA STREPTOCOCC

人类牙菌斑细菌链球菌之间的种间通讯

• 批准号: 7381715
• 负责人: Paul Egland
• 金额: $ 1.55万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381715
• 关键词: INTERSPECIES; COMMUNICATION; BETWEEN; HUMAN; DENTAL

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The human oral biofilm, dental plaque, is a well-recognized example of multi-species bacterial community. Dr. Egland's research lies in the study of communication between different species of bacteria that compose dental plaque. This communication includes cell-cell contact and metabolic interactions between organisms in the biofilm. The current research focus is communication that occurs between two members of the plaque community, Veillonella atypica and Streptococcus gordonii. When these organisms are growing together, S. gordonii induces expression of an alpha-amylase gene that is not expressed when S. gordonii is grown without V. atypica. The goals are to identify the mechanism of signaling that occurs between these species and determine the importance of amylase expression to development of the mixed-species community. In the future, genomic and proteomic approaches will be used to identify other genes that are induced by interspecies communication.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。人类口腔生物膜，牙菌斑，是一个公认的多物种细菌群落的例子。Egland博士的研究在于研究组成牙菌斑的不同细菌之间的交流。这种交流包括生物膜中生物体之间的细胞-细胞接触和代谢相互作用。目前的研究重点是两个成员之间发生的斑块社区，韦荣氏球菌和链球菌戈登。当这些生物生长在一起时，S。gordonii诱导α-淀粉酶基因的表达，该基因在S. gordonii在没有V.目的是确定这些物种之间发生的信号传导机制，并确定淀粉酶表达对混合物种群落发展的重要性。将来，基因组学和蛋白质组学的方法将被用来确定其他基因，诱导种间通信。