COBRE: U OF KANSAS MEDICAL CTR: CORE E: ANALYTICAL CORE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。分析核心将通过在应用于研究问题方面提供仪器和专业知识，为科布雷项目的研究人员提供支持。具体地说，分析核心将为我们的研究人员提供和推广高效液相色谱、LC MS/MS、FPLC和多模式分光光度作为分析工具。这一核心将为Cobre研究人员提供现代仪器方法，用于分离、鉴定和量化与他们对健康和疾病的肝功能研究相关的化合物。我们将验证仪器性能，将其作为这一核心设施整体质量保证计划的组成部分。该核心将协助和培训Cobre调查人员进行适当的采样和样品准备，以利用这些仪器方法。最后，分析核心将与该校园和该州其他校园的其他核心设施建立工作关系，以进一步发展所有核心的能力和效率

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Analytical Core will support the investigators of the COBRE projects by providing instrumentation arid expertise in its application to research problems. Specifically, the Analytical Core will provide and promote HPLC, LCMS/MS, FPLC, and multi-mode spectrophotometry as analytical tools available to our investigators. This Core will provide COBRE investigators with modern instrumental approaches for the isolation, identification, and quantification of compounds of relevance to their studies of liver function in health and disease. We will validate instrument performance as a component of an overall quality assurance program for this core facility. This Core will assist and train COBRE investigators in appropriate sampling and sample preparation to take advantage of these instrumental approaches. Finally, the Analytical Core will develop working relationships with other Core Facilities on this campus and on other campuses in the state to further develop the capabilities and the efficiency of all Cores