COBRE: U OF KANSAS MEDICAL CTR: ANALYTICAL CORE

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 分析核心将支持COBRE项目的研究人员，提供仪器和专业知识，将其应用于研究问题。具体而言，分析核心将提供和促进HPLC，LC-MS/MS，FPLC和多模式分光光度法作为我们研究人员可用的分析工具。该核心将为COBRE研究人员提供现代仪器方法，用于分离，鉴定和定量与健康和疾病中肝功能研究相关的化合物。我们将验证仪器性能，作为该核心设施整体质量保证计划的组成部分。 该核心将协助和培训COBRE调查人员进行适当的取样和样品制备，以利用这些仪器方法。最后，分析核心将与该校区和该州其他校区的其他核心设施建立工作关系，以进一步发展所有核心的能力和效率。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Analytical Core will support the investigators of the COBRE projects by providing instrumentation and expertise in its application to research problems. Specifically, the Analytical Core will provide and promote HPLC, LC-MS/MS, FPLC, and multi-mode spectrophotometry as analytical tools available to our investigators. This Core will provide COBRE investigators with modern instrumental approaches for the isolation, identification, and quantification of compounds of relevance to their studies of liver function in health and disease. We will validate instrument performance as a component of an overall quality assurance program for this core facility. This Core will assist and train COBRE investigators in appropriate sampling and sample preparation to take advantage of these instrumental approaches. Finally, the Analytical Core will develop working relationships with other Core Facilities on this campus and on other campuses in the state to further develop the capabilities and the efficiency of all Cores.