Neuroreceptor Imaging of Tobacco Smokers

吸烟者的神经感受器成像

• 批准号: 7493531
• 负责人: JULIE K STALEY
• 金额: $ 12.61万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7493531
• 关键词: Abstinence; Address; Age; Alcohol dependence; Aminobutyric Acid; Aminobutyric Acids; Anxiety; Autopsy; Award; Benzodiazepine Receptor; Binding; Brain; Brain imaging; Carbon Monoxide; Chemicals; Cigarette; Cognitive; Cotinine; Daily; Development; Development Plans; Educational Curriculum; Extramural Activities; Female; Funding; Future; Genetic; Gonadal Steroid Hormones; Human; Image; Independent Scientist Award; Investigation; Knowledge; Life; Measurement; Measures; Menstrual cycle; Mental Depression; Mood Disorders; National Institute on Alcohol Abuse and Alcoholism; Neuropsychology; Neurotransmitters; Nicotine; Nicotinic Receptors; Numbers; Peer Review; Pharmacotherapy; Positron-Emission Tomography; Productivity; Psychological reinforcement; Publications; Race; Regulation; Research; Research Design; Research Personnel; Role; Sensory Receptors; Sex Characteristics; Smoke; Smoker; Smoking; Time; Tobacco; Tobacco smoke; Tobacco smoking; Training; Transdisciplinary Tobacco Research Center; Urine; Week; Woman; base; career; craving; day; depressive symptoms; gamma-Aminobutyric Acid; image processing; iomazenil; mathematical model; men; neurochemistry; nicotine replacement; non-smoker; proliferative phase Menstrual cycle; research study; response; sex; single photon emission computed tomography; skills; smoking cessation; symposium; uptake

DESCRIPTION (provided by applicant): This K02 application seeks continued support essential for my continued career development as a newly independent researcher of PET and SPECT neuroreceptor imaging in tobacco smokers. Through a K01 funded by NIAAA, I attained considerable expertise in the brain imaging of smokers with and without alcohol dependence. While conducting these studies, I realized the paucity of knowledge on the neuro-chemical consequences of tobacco smoking and decided to focus my future efforts predominantly in the field of tobacco smoking. I have demonstrated considerable research productivity as evidenced by my peer reviewed publications, my principal-investigatorship of a R01 (DA015577) and a primary project in the Yale Transdisciplinary Tobacco Use Research Center (TTURC). I have acquired significantly more administrative responsibilities in the past year, which will increase in 2006, thus, this K02 award is vital for providing 80% focused research time and for facilitating my maturation into a fully-independent investigator. Justification for the award is provided by a comprehensive 5-year Career Development Plan that fills important gaps and compliments my current expertise in SPECT/PET neuroreceptor imaging. Specifically, I will acquire specialized skills in: 1) image processing and analysis 2) mathematical modeling for neuroreceptor quantitation, 3) genetics, and 4) cognitive neuropsychology. Intensive training is provided by an integrated curriculum of intramural coursework, extramural didactics, individualized preceptorships, interactive symposia, and research-related organizational meetings. Two representative, funded research studies are included that address major hypotheses involving the role of the nicotinic acetylcholine receptor and the GABAA-benzodiazepine receptor in habitual tobacco smoking in humans. These investigations illustrate the impact this career award will have in furthering not only my scientific career, but also our fundamental understanding of the neurochemical mechanisms underlying habitual tobacco smoking.

描述（由申请人提供）：该K02申请为我在烟草吸烟者中的宠物和SPECT神经感受器成像的新独立研究人员的持续职业发展寻求持续的支持。通过NIAAA资助的K01，我在具有和没有酒精依赖的吸烟者的大脑成像方面获得了相当大的专业知识。在进行这些研究时，我意识到烟草吸烟的神经化学后果的知识很少，并决定将未来的努力主要集中在吸烟领域。我已经证明了相当大的研究生产力，我的同行评审出版物，我对R01（DA015577）的主要投资者职位以及耶鲁跨学科烟草使用研究中心（TTURC）的主要项目所证明。在过去的一年中，我已经获得了更多的行政责任，这将在2006年增加，因此，这一K02奖对于提供80％的重点研究时间并促进我成熟到完全独立的研究人员至关重要。该奖项的理由是由一项全面的5年职业发展计划提供的，该计划填补了重要的空白，并补充了我目前在SPECT/PET神经受体成像方面的专业知识。具体而言，我将获得以下方面的专业技能：1）图像处理和分析2）神经受体定量的数学建模，3）遗传学和4）认知神经心理学。强化培训是由校园内课程，壁外教学，个性化录取，互动研讨会和与研究相关的组织会议的综合课程提供的。包括两项代表性的，资助的研究，这些研究涉及涉及烟碱乙酰胆碱受体和Gabaa-Benzodiazepine受体在人类吸烟中的作用的主要假设。这些调查说明了这一职业奖的影响，不仅会进一步进一步发展我的科学生涯，而且还将进一步发展我们对习惯性烟草潜在的神经化学机制的基本理解。