Cognition, Tobacco Smoke and Nicotinic Receptor Occupancy

认知、烟草烟雾和烟碱受体占用

• 批准号: 7145724
• 负责人: JULIE K STALEY
• 金额: $ 12.21万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-10 至 2008-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7145724
• 关键词: clinical research; cognition; nicotine; nicotinic receptors; performance; smoking; tobacco abuse

DESCRIPTION (provided by applicant): Cognition, Tobacco Smoke and Nicotinic Receptor Occupancy Tobacco smoking has beneficial effects on cognition. In some cases smoking improves cognitive performance and in others it reverses deficits brought on by smoking deprivation. Many of the cognitive enhancing effects of smoking have been attributed to the pharmacological actions of nicotine on nicotinic acetylcholine receptors (nAChR). Nicotine improves performance on working memory tasks, motor response tests of focused and sustained attention and recognition memory. In addition to nicotine, tobacco smoke includes approximately 4000 additional compounds, of which many are pharmacologically active and may contribute to the effects of smoking on cognition. The cognitive effects of nicotine versus tobacco smoke have not yet been delineated. Moreover it is not clear how the degree of nicotine occupancy of brain nicotinic acetylcholine receptors (nAChR ) is correlated with cognitive performance. In the present study we propose to explore the effects of tobacco smoke, denicotinized tobacco smoke and nicotine on performance on cognitive tasks of attention, learning, memory, speed of information processing and executive functions in smokers while they are actively smoking; after 12 -24 h abstinence; after 7 days abstinence and after smoking a nicotine-containing cigarette; a de-nicotinized cigarette and after using the nicotine inhaler. The relationship between cognitive performance and the number of brain (32-nAChR and the amount of nicotine delivered to cortical and subcortical brain areas will be measured using [123I] 5-IA-85380 and SPECT. These exploratory studies will delineate the role of nicotine versus denicotinized tobacco smoke on cognitive performance in acutely abstinent smokers. In addition they will provide critical information about the interaction of nicotine with p2-nAChR and the relationship to improvements in cognitive performance.

描述（由申请人提供）：认知、烟草烟雾和烟碱受体占用 吸烟对认知有有益影响。在某些情况下，吸烟可以改善认知能力，而在另一些情况下，吸烟可以逆转因剥夺吸烟而带来的缺陷。吸烟的许多认知增强作用归因于尼古丁对烟碱乙酰胆碱受体（nAChR）的药理作用。尼古丁可以提高工作记忆任务、集中和持续注意力的运动反应测试以及识别记忆的表现。除尼古丁外，烟草烟雾还含有大约 4000 种其他化合物，其中许多化合物具有药理活性，可能会导致吸烟对认知的影响。尼古丁与烟草烟雾对认知的影响尚未明确。此外，尚不清楚大脑烟碱乙酰胆碱受体（nAChR）的尼古丁占用程度如何与认知能力相关。在本研究中，我们建议探讨烟草烟雾、脱烟碱烟草烟雾和尼古丁对吸烟者主动吸烟时注意力、学习、记忆、信息处理速度和执行功能等认知任务表现的影响； 12 -24小时禁欲后；戒烟 7 天后以及吸食含尼古丁的香烟后；脱尼古丁香烟以及使用尼古丁吸入器后。将使用 [123I] 5-IA-85380 和 SPECT 测量认知表现与大脑数量（32-nAChR 以及输送到皮质和皮质下大脑区域的尼古丁量）之间的关系。这些探索性研究将描述尼古丁与脱尼古丁烟草烟雾对急性戒烟者认知表现的作用。此外，它们还将提供有关尼古丁与脱尼古丁相互作用的重要信息。 p2-nAChR 及其与认知能力改善的关系。