Clinical Relevance of GB Virus C & Hepatitis C Virus in HIV+ Women

GB 病毒 C 的临床相关性

• 批准号: 7755157
• 负责人: JASON T BLACKARD
• 金额: $ 23.55万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-02 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7755157
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Basic Science; CD4 Lymphocyte Count; Clinical Research; Collaborations; Communicable Diseases; Data; Diagnosis; Disease; Disease Progression; Drug usage; Family; Flaviviridae; Future; GB virus; GB virus C; Gender; Gene Mutation; Genotype; HCV Liver Disease; HIV; HIV Seropositivity; Health; Hepatitis C virus; High Prevalence; High Risk Woman; Individual; Infection; Injection of therapeutic agent; Interferons; Knowledge; Laboratories; Lead; Literature; Liver; Liver diseases; Longitudinal Studies; Measures; Mediating; Morbidity - disease rate; Opportunistic Infections; Outcome; Overdose; Participant; Persons; Population; Prevalence; Prospective Studies; Publications; RNA; RNA Viruses; Receptor Gene; Relative (related person); Reporting; Resources; Role; Serological; Sex Characteristics; Substance abuse problem; Time; Treatment outcome; Universities; Vascular blood supply; Viremia; Virus; Virus Diseases; Virus Replication; Woman; Work; abstracting; antiretroviral therapy; clinically relevant; cohort; ethnic minority population; experience; human disease; in vivo; innovation; male; men; mortality; novel therapeutics; public health relevance; racial and ethnic; treatment strategy

DESCRIPTION (provided by applicant): (GBV-C) is a single-stranded RNA virus that is the closest known relative of hepatitis C virus (HCV). GBV-C has not been associated with any human disease to date. However, several studies have reported a beneficial effect of GBV-C viremia on HIV disease progression - reduced HIV RNA levels, increased CD4 cell counts, and slower disease progression - predominantly in cohorts with a high proportion of men. However, the prevalence of GBV-C differs significantly between men and women, and no large prospective studies have examined the effects of GBV-C co-infection on HIV disease progression in women. In a preliminary study, we found that GBV-C genotype 2 was associated with higher CD4 cell counts compared to genotype 1, and that GBV-C genotype 2 was more sensitive to clearance after interferon treatment than GBV-C genotype 1. Therefore, we propose to evaluate the presence of GBV-C co-infection and the role of GBV-C genotype in modulating HIV disease progression in a well-characterized cohort of women with HIV/AIDS to enhance our knowledge of GBV-C/HIV interactions. This work is significant and innovative because no large prospective studies of the role of GBV-C co-infection in modulating HIV disease have been reported in HIV positive women and because its addresses a potentially beneficial interaction between GBV-C and HIV that could be exploited in the future to develop novel therapeutic strategies. PUBLIC HEALTH RELEVANCE: To date, GB virus type C (GBV-C) has not been associated with any human disease, although several studies have reported a beneficial effect of GBV-C infection on HIV disease progression. The prevalence of GBV-C may differ by gender; however, the adventitious role of GBV-C co-infection on HIV disease, as well as the potential modulatory effects of GBV-C genotype, has not yet been evaluated in a longitudinal manner in women. Such studies could ultimately lead to novel therapeutic strategies to treat HIV disease, particularly among difficult-to-treat populations and/or individuals with limited access to antiretroviral therapy.

描述（由申请人提供）：（GBV-C）是一种单链RNA病毒，是已知的与丙型肝炎病毒（HCV）最近的近亲。迄今为止，GBV-C尚未与任何人类疾病相关。然而，一些研究报告了GBV-C病毒血症对HIV疾病进展的有益影响——降低HIV RNA水平，增加CD4细胞计数，减缓疾病进展——主要是在男性比例较高的队列中。然而，GBV-C的患病率在男性和女性之间存在显著差异，并且没有大型前瞻性研究调查GBV-C合并感染对女性艾滋病毒疾病进展的影响。在初步研究中，我们发现GBV-C基因2型与基因1型相比，CD4细胞计数更高，并且GBV-C基因2型比GBV-C基因1型对干扰素治疗后的清除更敏感。因此，我们建议在一个特征明确的HIV/AIDS女性队列中评估GBV-C合并感染的存在以及GBV-C基因型在调节HIV疾病进展中的作用，以增强我们对GBV-C/HIV相互作用的了解。这项工作具有重大意义和创新性，因为在艾滋病毒阳性妇女中没有关于GBV-C联合感染在调节艾滋病毒疾病中的作用的大型前瞻性研究，而且因为它解决了GBV-C和艾滋病毒之间潜在的有益相互作用，可以在未来开发新的治疗策略。公共卫生相关性：迄今为止，GB病毒C型（GBV-C）尚未与任何人类疾病相关，尽管有几项研究报道了GBV-C感染对HIV疾病进展的有益影响。GBV-C的患病率可能因性别而异；然而，GBV-C合并感染对HIV疾病的非确定作用，以及GBV-C基因型的潜在调节作用，尚未在女性中以纵向方式进行评估。这些研究最终可能导致新的治疗策略来治疗艾滋病毒疾病，特别是在难以治疗的人群和/或获得抗逆转录病毒治疗机会有限的个人中。