Omics analysis of HIV during synthetic opioid exposure

合成阿片类药物暴露期间 HIV 的组学分析

• 批准号: 10158901
• 负责人: JASON T BLACKARD
• 金额: $ 15.02万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10158901
• 关键词: 2019-nCoV; Antiviral Agents; Area; CD4 Positive T Lymphocytes; COVID-19; China; Data; Disease Outbreaks; Disease Progression; Drug Addiction; Epidemiology; Fentanyl; Foundations; Future; Growth; HIV; HIV Infections; HIV Seropositivity; Immunosuppression; In Vitro; Infection; Injecting drug user; Institutes; Location; Medicine; MicroRNAs; Morbidity - disease rate; Names; National Institute of Drug Abuse; Ohio; Opioid; Opioid Receptor; Overdose; Parents; Pathogenesis; Peripheral Blood Mononuclear Cell; Persons; Pharmaceutical Preparations; Pneumonia; Population Study; Prevalence; Proteins; Publishing; Reporting; Research; Research Personnel; Risk; Severity of illness; Signal Pathway; Signal Transduction; Substance abuse problem; System; Testing; Therapeutic; United States Food and Drug Administration; Universities; Vaccines; Viral; Viral Pathogenesis; Virus; Virus Activation; Virus Diseases; Virus Replication; Work; addiction; advanced disease; biosafety level 3 facility; cell type; co-infection; college; comorbidity; drug of abuse; high risk population; in vivo; innovation; macrophage; monocyte; mortality; novel coronavirus; opioid epidemic; opioid exposure; opioid overdose; opioid use disorder; pandemic disease; pathogenic virus; reactivation from latency; synthetic opioid; transcription factor; transmission process; virology

Abstract In December 2019, an outbreak of pneumonia of unknown cause occurred in Wuhan, China, and the causative agent was identified as a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Additionally, the US is in the midst of a major opioid epidemic largely attributed to synthetic opioids such as fentanyl, and the SARS-CoV-2 pandemic is occurring in parts of the world where recent increases in HIV due to the opioid crisis have been reported. With the SARS-CoV-2 pandemic, there are major concerns about worsening of the opioid crisis. People suffering from addiction are particularly vulnerable to increased infection with SARS-CoV-2 and more advanced disease severity. Many opioids are also associated with immune suppression and enhanced viral pathogenesis. Thus, foundational research on virus-virus and virus-opioid interactions is essential for understanding the impact of SARS-CoV-2 on other co- morbid conditions and for developing robust therapeutic options for limiting viral infection and pathogenesis in high-risk populations.

摘要

项目成果

The Synthetic Opioid Fentanyl Increases HIV Replication and Chemokine Co-Receptor Expression in Lymphocyte Cell Lines.

• DOI: 10.3390/v15041027
• 发表时间: 2023-04-21
• 期刊: Viruses
• 作者: Madhuravasal Krishnan J;Kong L;Karns R;Medvedovic M;Sherman KE;Blackard JT
• 通讯作者: Blackard JT

Drugs of Abuse and Their Impact on Viral Pathogenesis.

• DOI: 10.3390/v13122387
• 发表时间: 2021-11-29
• 期刊: Viruses
• 作者: Blackard JT;Sherman KE
• 通讯作者: Sherman KE