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Omics analysis of HIV during synthetic opioid exposure

合成阿片类药物暴露期间 HIV 的组学分析

基本信息

批准号：
10158901
负责人：
JASON T BLACKARD
金额：
$ 15.02万
依托单位：
UNIVERSITY OF CINCINNATI
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-03-01 至 2021-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10158901
关键词：
2019-nCoV Antiviral Agents Area CD4 Positive T Lymphocytes COVID-19 China Data Disease Outbreaks Disease Progression Drug Addiction Epidemiology Fentanyl Foundations Future Growth HIV HIV Infections HIV Seropositivity Immunosuppression In Vitro Infection Injecting drug user Institutes Location Medicine MicroRNAs Morbidity - disease rate Names National Institute of Drug Abuse Ohio Opioid Opioid Receptor Overdose Parents Pathogenesis Peripheral Blood Mononuclear Cell Persons Pharmaceutical Preparations Pneumonia Population Study Prevalence Proteins Publishing Reporting Research Research Personnel Risk Severity of illness Signal Pathway Signal Transduction Substance abuse problem System Testing Therapeutic United States Food and Drug Administration Universities Vaccines Viral Viral Pathogenesis Virus Virus Activation Virus Diseases Virus Replication Work addiction advanced disease biosafety level 3 facility cell type co-infection college comorbidity drug of abuse high risk population in vivo innovation macrophage monocyte mortality novel coronavirus opioid epidemic opioid exposure opioid overdose opioid use disorder pandemic disease pathogenic virus reactivation from latency synthetic opioid transcription factor transmission process virology

项目摘要

Abstract In December 2019, an outbreak of pneumonia of unknown cause occurred in Wuhan, China, and the causative agent was identified as a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Additionally, the US is in the midst of a major opioid epidemic largely attributed to synthetic opioids such as fentanyl, and the SARS-CoV-2 pandemic is occurring in parts of the world where recent increases in HIV due to the opioid crisis have been reported. With the SARS-CoV-2 pandemic, there are major concerns about worsening of the opioid crisis. People suffering from addiction are particularly vulnerable to increased infection with SARS-CoV-2 and more advanced disease severity. Many opioids are also associated with immune suppression and enhanced viral pathogenesis. Thus, foundational research on virus-virus and virus-opioid interactions is essential for understanding the impact of SARS-CoV-2 on other co- morbid conditions and for developing robust therapeutic options for limiting viral infection and pathogenesis in high-risk populations.

摘要 2019年12月，中国武汉发生不明原因的肺炎疫情，病原体被鉴定为一种名为严重急性呼吸综合征冠状病毒的新型冠状病毒 2（SARS-CoV-2）。此外，美国正处于一个主要的阿片类药物流行病，主要是由于合成阿片类药物，如芬太尼，和SARS-CoV-2大流行正在发生在世界上的一些地区，据报道，阿片类药物危机导致艾滋病毒感染率上升。随着SARS-CoV-2大流行，对阿片类药物危机恶化的主要担忧。患有成瘾症的人尤其易受SARS-CoV-2感染增加和疾病严重程度加重的影响。许多阿片类药物还与免疫抑制和增强的病毒发病机制有关。因此，基础研究病毒-病毒和病毒-阿片类药物相互作用对于理解SARS-CoV-2对其他共同疾病状况，并开发强大的治疗选择，以限制病毒感染和发病机制，高危人群。