Omics analysis of HIV during synthetic opioid exposure
合成阿片类药物暴露期间 HIV 的组学分析
基本信息
- 批准号:10548205
- 负责人:
- 金额:$ 60.46万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-03-01 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAlcoholsAreaBioinformaticsCD4 Positive T LymphocytesCell CommunicationClinicCocaineCommunitiesComplexDataDisease ProgressionEpidemicEquipmentFentanylHIVHIV InfectionsHIV Long Terminal RepeatHIV SeropositivityHIV diagnosisHealth Services AccessibilityHeroinIn VitroIndividualInstitutionKnowledgeLiteratureLocationLong Terminal RepeatsMacrophageMediatingMedicineMethadoneMethamphetamineMicroRNAsMidwestern United StatesMorbidity - disease rateMorphineOhioOpioidOpioid ReceptorOverdosePathologyPathway interactionsPatientsPeripheral Blood Mononuclear CellPersonsPharmaceutical PreparationsPredispositionPrevention programRNARecreationResearchRiskSeriesSignal PathwaySignal TransductionSubstance abuse problemTechnologyTranslational ResearchUniversitiesViralVirusaddictionadverse outcomecell typecollegecomorbidityexperimental studyfentanyl usefundamental researchhigh rewardhigh riskhigh risk sexual behaviorin vivoinjection drug usemonocytemortalitynovelopioid abuseopioid epidemicopioid exposureopioid useopioid use disorderopioid userreactivation from latencysingle-cell RNA sequencingsynthetic opioidtranscription factortranscriptometransmission processtreatment optimization
项目摘要
Abstract
The US is in the midst of a major opioid epidemic largely attributed to synthetic opioids. For example,
fentanyl is 50-100 times more potent than heroin and is involved in >60% of overdoses nationwide and >90%
of overdoses in Ohio, although this is almost certainly an underestimate of recreational use. Individuals with
opioid use disorder are at significant risk for transmission of HIV, and new cases of HIV are on the rise in the
Midwest and at our institution. Opioid receptors are expressed in a variety of cell types that are susceptible
to HIV infection. Commonly abused opioids promote HIV replication and virus-mediated pathology. Thus,
translational research on virus-opioid interactions is essential for optimized treatment and limiting viral
reactivation. Important knowledge regarding how synthetic opioids influence HIV latency and reactivation is
absent from the available literature. To fill this critical gap and institute a major shift forward in our
understanding of this epidemic, we propose a series of complementary in vivo studies to directly evaluate the
impact of synthetic opioids on markers of HIV latency/reactivation, viral diversity, transcription factor
expression, microRNA expression, and cell signaling pathways.
摘要
美国正处于一场主要的阿片类药物流行之中,这在很大程度上归因于合成阿片类药物。例如,
芬太尼的效力是海洛因的50-100倍,全国60%的过量用药与芬太尼有关,90%的过量用药与芬太尼有关
俄亥俄州的过量使用,尽管这几乎可以肯定低估了娱乐用途。具有以下特征的个人
阿片类药物使用障碍有很大的艾滋病毒传播风险,新的艾滋病毒病例正在上升。
在中西部和我们的机构。阿片受体在多种易感细胞中表达。
对艾滋病病毒的感染。通常滥用的阿片类药物会促进艾滋病毒复制和病毒介导的病理。因此,
对病毒-阿片类药物相互作用的翻译研究对于优化治疗和限制病毒是必不可少的
重新激活。关于合成阿片类药物如何影响艾滋病毒潜伏期和重新激活的重要知识
没有出现在现有的文献中。为了填补这一关键空白,并在我们的
为了了解这种流行病,我们提出了一系列补充的体内研究,以直接评估
合成阿片类药物对HIV潜伏/再激活标志物、病毒多样性、转录因子的影响
表达、微RNA表达和细胞信号通路。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('JASON T BLACKARD', 18)}}的其他基金
Therapeutic and mechanistic significance of altered metabolism of HIV medicines by alcohol- or alcohol/synthetic opioid combination
酒精或酒精/合成阿片类药物组合改变 HIV 药物代谢的治疗和机制意义
- 批准号:
10542286 - 财政年份:2022
- 资助金额:
$ 60.46万 - 项目类别:
Therapeutic and mechanistic significance of altered metabolism of HIV medicines by alcohol- or alcohol/synthetic opioid combination
酒精或酒精/合成阿片类药物组合改变 HIV 药物代谢的治疗和机制意义
- 批准号:
10700069 - 财政年份:2022
- 资助金额:
$ 60.46万 - 项目类别:
Viral and host predictors of BK polyomavirus associated hemorrhagic cystitis
BK 多瘤病毒相关出血性膀胱炎的病毒和宿主预测因子
- 批准号:
10203959 - 财政年份:2020
- 资助金额:
$ 60.46万 - 项目类别:
Viral and host predictors of BK polyomavirus associated hemorrhagic cystitis
BK 多瘤病毒相关出血性膀胱炎的病毒和宿主预测因子
- 批准号:
10434701 - 财政年份:2020
- 资助金额:
$ 60.46万 - 项目类别:
Viral and host predictors of BK polyomavirus associated hemorrhagic cystitis
BK 多瘤病毒相关出血性膀胱炎的病毒和宿主预测因子
- 批准号:
10653831 - 财政年份:2020
- 资助金额:
$ 60.46万 - 项目类别:
Viral and host predictors of BK polyomavirus associated hemorrhagic cystitis
BK 多瘤病毒相关出血性膀胱炎的病毒和宿主预测因子
- 批准号:
10029242 - 财政年份:2020
- 资助金额:
$ 60.46万 - 项目类别:
Omics analysis of HIV during synthetic opioid exposure
合成阿片类药物暴露期间 HIV 的组学分析
- 批准号:
9883771 - 财政年份:2019
- 资助金额:
$ 60.46万 - 项目类别:
Omics analysis of HIV during synthetic opioid exposure
合成阿片类药物暴露期间 HIV 的组学分析
- 批准号:
10158901 - 财政年份:2019
- 资助金额:
$ 60.46万 - 项目类别:
Genotypic& phenotypic characterization of the HCV polymerase (NS5B) in HIV
基因型
- 批准号:
9267990 - 财政年份:2013
- 资助金额:
$ 60.46万 - 项目类别:
Genotypic& phenotypic characterization of the HCV polymerase (NS5B) in HIV
基因型
- 批准号:
8466568 - 财政年份:2013
- 资助金额:
$ 60.46万 - 项目类别:
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