Role of MSK in chromatin remodelling underlying stress-induced transcriptional induction in dentate gyrus granule neurons and behavioural adaptation

MSK 在齿状回颗粒神经元应激诱导转录诱导和行为适应染色质重塑中的作用

• 批准号: BB/F000510/1
• 负责人: Johannes Reul
• 金额: $ 43.2万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FF000510%2F1
• 关键词: Role; MSK; chromatin; remodelling; underlying

Stress is part of everybody's every day life. We need to respond appropriately to stressful events and normally we learn from them to cope better the next time they are imposed on us. These learning and adaptation processes are taking place in the brain. These processes must work properly as improper functioning can cause illness such as depression and anxiety. However, we currently do not fully know how the brain learns from stressful events. We have recently discovered that after stress certain molecular processes ('histone modifications') are taking place in the nucleus of nerve cells which we think are crucial for the expression of certain genes necessary for the adaptation of these cells to the stressful event. These processes are triggered by certain hormones which are released within the brain or by hormone glands and that bind to receptors on the cell surface or inside these cells. The hormones do not trigger the molecular processes in the nucleus directly but do so via so-called signalling molecules. Our proposal aims to identify those signalling molecules and determine how these molecules act in order to gain insight into how nerve cells 'learn' from stressful events.

压力是每个人日常生活的一部分。我们需要对压力事件做出适当的反应，通常我们会从中学习，以便在下一次强加给我们时更好地科普。这些学习和适应过程都发生在大脑中。这些过程必须正常运作，因为不正常的运作可能会导致抑郁和焦虑等疾病。然而，我们目前还不完全知道大脑如何从压力事件中学习。我们最近发现，在压力之后，某些分子过程（“组蛋白修饰”）在神经细胞的细胞核中发生，我们认为这对于这些细胞适应压力事件所必需的某些基因的表达至关重要。这些过程是由大脑或激素腺体释放的某些激素触发的，这些激素与细胞表面或细胞内部的受体结合。激素并不直接触发细胞核中的分子过程，而是通过所谓的信号分子来触发。我们的建议旨在识别这些信号分子，并确定这些分子如何发挥作用，以便深入了解神经细胞如何从压力事件中“学习”。

项目成果

Brain, Behavior and Epigenetics

大脑、行为和表观遗传学

• 发表时间: 2011
• 作者: Reul, Johannes M.H.M.

The Handbook of Stress - Neuropsychological Effects on the Brain

压力手册 - 对大脑的神经心理影响

• DOI: 10.1002/9781118083222.ch5
• 发表时间: 2011
• 作者: Reul J