LTP: A mechanism for object-place learning in the prefrontal cortex ?

识别记忆是日常生活中必不可少的。它涉及到我们判断以前是否遇到过什么事情的能力。为了做出这些判断，我们能够使用一系列不同的记忆过程。例如，我们可以根据我们是否在特定环境、位置或上下文中看到过刺激，即之前是否在特定位置看到或遇到过某个对象，来进行再认记忆判断。这一提议的假设是，这种特殊的记忆过程(称为物体在地记忆)在大脑的一个区域--前额叶皮质内受到控制。有人提出，记忆的形成和存储依赖于神经元之间联系的加强，因此增加了脑细胞之间的沟通。这些实验的目的是了解前额叶皮质脑细胞内可能发生的导致它们之间交流增加的过程，并检查物体就地记忆的形成和存储是否需要这些相同的过程。这样的研究将让我们更好地理解我们是如何在大脑中学习和存储记忆信息的。

Recognition memory is essential to every day life. It involves our ability to judge whether or not we have encountered something previously. To make these judgements we are able to use a range of different memory processes. For example, we can make recognition memory judgement based upon whether we have seen a stimulus within a particular environment, location or context i.e. whether an object has been seen or encountered previously in a particular place. The hypothesis of this proposal is that this particular memory processes (called object-in-place memory) is controlled within a region of the brain, the prefrontal cortex. It has been proposed that the formation and storage of memory relies on the strengthening of the connections between neurones, and therefore increased communication between brain cells. The aim of the experiments is to understand the processes which may be occurring within brain cells in the prefrontal cortex which result in increased communication between them, and to examine whether the formation and storage of object-in-place memories requires these same processes. Such research willl allow a greater understanding of how we are able to learn and store memory information in the brain.