LTP: A mechanism for object-place learning in the prefrontal cortex ?

LTP：前额皮质中物体位置学习的机制？

• 批准号: BB/F00236X/1
• 负责人: Zafar Bashir
• 金额: $ 50.05万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FF00236X%2F1
• 关键词: LTP; mechanism; object; place; learning

Recognition memory is essential to every day life. It involves our ability to judge whether or not we have encountered something previously. To make these judgements we are able to use a range of different memory processes. For example, we can make recognition memory judgement based upon whether we have seen a stimulus within a particular environment, location or context i.e. whether an object has been seen or encountered previously in a particular place. The hypothesis of this proposal is that this particular memory processes (called object-in-place memory) is controlled within a region of the brain, the prefrontal cortex. It has been proposed that the formation and storage of memory relies on the strengthening of the connections between neurones, and therefore increased communication between brain cells. The aim of the experiments is to understand the processes which may be occurring within brain cells in the prefrontal cortex which result in increased communication between them, and to examine whether the formation and storage of object-in-place memories requires these same processes. Such research willl allow a greater understanding of how we are able to learn and store memory information in the brain.

识别记忆对于日常生活至关重要。它涉及我们判断我们以前是否遇到过某件事的能力。为了做出这些判断，我们可以使用一系列不同的记忆过程。例如，我们可以根据我们是否在特定的环境、位置或上下文中看到过刺激物，即之前是否在特定的地方看到或遇到过某个物体，来做出识别记忆判断。该提议的假设是，这种特定的记忆过程（称为物体就地记忆）是在大脑的前额叶皮层区域内控制的。有人提出，记忆的形成和存储依赖于神经元之间连接的加强，从而增加脑细胞之间的交流。实验的目的是了解前额皮质脑细胞内可能发生的过程，这些过程会导致它们之间的交流增加，并检查就地物体记忆的形成和存储是否需要这些相同的过程。此类研究将使我们更好地了解我们如何在大脑中学习和存储记忆信息。

项目成果

Regionally selective requirement for D1/D5 dopaminergic neurotransmission in the medial prefrontal cortex in object-in-place associative recognition memory.

• DOI: 10.1101/lm.036921.114
• 发表时间: 2015-02
• 期刊: Learning & memory (Cold Spring Harbor, N.Y.)
• 作者: Savalli G;Bashir ZI;Warburton EC
• 通讯作者: Warburton EC