Quantitative Metabolomic Analysis of Chronic Exposures to Environmental Toxicants
长期暴露于环境毒物的定量代谢组学分析
基本信息
- 批准号:7414045
- 负责人:
- 金额:$ 14.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-05-08 至 2009-04-30
- 项目状态:已结题
- 来源:
- 关键词:AntioxidantsArtsAutopsyBioinformaticsBiological MarkersBrainBrain regionC57BL/6 MouseCell DeathChronicClinicalCoupledCyclotronsDataDevelopmentDevelopment PlansDieldrinDisruptionDopamineDopaminergic CellEarly DiagnosisEngineeringEnvironmental Engineering technologyEtiologyExposure toFosteringFourier TransformGlutathioneGlutathione DisulfideGoalsHealthHeptachlorHigh Pressure Liquid ChromatographyHumanInsecticidesInstitutesInterventionIon ExchangeIonsLaboratoriesLearningLindaneLiquid ChromatographyLiteratureMass Spectrum AnalysisMeasuresMentorsMentorshipMetabolicMethodsMusNMR SpectroscopyNeurodegenerative DisordersNeurologyNuclear Magnetic ResonanceOrganismOxidation-ReductionOxidative StressParkinson DiseasePathogenesisPatientsPlasmaPlayPolychlorinated BiphenylsProteinsPublic HealthResearchResearch PersonnelResearch Project GrantsResolutionRiskRoleSamplingSchoolsScienceSpectrum AnalysisSubstantia nigra structureSystemTechniquesTechnologyTherapeutic InterventionTimeTissuesTitleToxic Environmental SubstancesToxicant exposureTrainingUSA GeorgiaUniversitiesVisitWestern Asia Georgiaanalytical methodbasebrain tissuecareercontaminant transportcostdisorder riskhuman tissuemetabolomicsneuromelaninneurotoxicologypollutantprofessorprogramsremediationresponseskillstoxicant
项目摘要
DESCRIPTION (provided by applicant)
Data compiled over the last two decades indicate that chronic exposure to persistent environmental toxicants, including polychlorinated biphenyls (PCBs) and chlorinated organic insecticides, increases the risk of developing neurodegenerative disease, such as Parkinson's disease (PD). Recent studies suggest that these toxicants contribute to elevated intracellular dopamine levels, increased oxidative stress, and ultimately dopaminergic cell death, a hallmark of PD. The primary objective of this proposal is to rapidly advance the career of the candidate in this field through a combination of didactic learning, mentored research, and multi-disciplinary proposal development. The candidate, Kurt D. Pennell, is an Associate Professor of Environmental Engineering in the School of Civil & Environmental Engineering at the Georgia Institute of Technology. The career development plan, which includes coursework in bioinformatics, advanced spectroscopy and neurotoxicology, builds upon his training in science and engineering, research on contaminant transport and remediation in subsurface systems, analytical skills, and on-going sabbatical in the Department of Neurology at Emory University. The proposed activities will be carried out at Georgia Tech and Emory, where the candidate holds the title of visiting Associate Professor. The underlying hypothesis of the proposed research is that biomarkers of oxidative stress and metabolomic profiles can be correlated to chronic toxicant exposures and neurodegenerative disease. Under the mentorship of Dean P. Jones, Professor and Director of the Emory Clinical Biomarkers Laboratory, the specific aims of the research project are to: 1) Quantify the accumulation and distribution of chlorinated organic compounds in postmortem human tissue and exposed C57BL/6 mice, 2) Assess metabolic disruption and oxidative stress using established HPLC methods and H1-nuclear magnetic resonance (NMR) spectroscopy, and 3) Develop and evaluate a high-throughput, quantitative metabolomic profiling method based on coupled ion exchange liquid chromatography and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR MS). Dr. Pennell's career goals are to establish an active research program in environmental metabolomics, play an integral role in multi-disciplinary research teams investigating chronic exposures to environmental toxicants, and to be a leader in fostering linkages between environmental engineering and biomedical sciences.
Relevance: The proposal is relevant to public health because it will advance our understanding of the relationship between chronic exposure to environmental toxicants and neurodegenerative disease, provide quantitative methods to rapidly screen for oxidative stress and adverse metabolic profiles, and offer the possibility for early detection and intervention.
描述(由申请人提供)
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kurt D. Pennell其他文献
Evaluation of co-foaming agents for enhanced removal of per-and polyfluoroalkyl substances (PFAS) by foam fractionation
用于通过泡沫分馏增强去除全氟和多氟烷基物质(PFAS)的共发泡剂的评估
- DOI:
10.1016/j.jhazmat.2025.138423 - 发表时间:
2025-08-15 - 期刊:
- 影响因子:11.300
- 作者:
Craig Klevan;Oren Van Allen;Shana Xia;Kelly Mukai;Andre Gomes;Seth Caines;Matthew J. Woodcock;Kurt D. Pennell - 通讯作者:
Kurt D. Pennell
Sorption-desorption processes contributing to the natural attenuation of emcis/em-1,2-dichloroethene in porous media
吸附-解吸过程对多孔介质中 emcis/em-1,2-二氯乙烯自然衰减的贡献
- DOI:
10.1016/j.jhazmat.2025.138500 - 发表时间:
2025-08-15 - 期刊:
- 影响因子:11.300
- 作者:
Katelyn A. Anderson;Uriel Garza-Rubalcava;Mark A. Widdowson;Eric J. Suchomel;Natalie L. Cápiro;Kurt D. Pennell - 通讯作者:
Kurt D. Pennell
Transport and competitive interfacial adsorption of PFOA and PFOS in unsaturated porous media: Experiments and modeling
- DOI:
10.1016/j.watres.2024.122728 - 发表时间:
2025-01-01 - 期刊:
- 影响因子:
- 作者:
Uriel Garza-Rubalcava;Craig Klevan;Kurt D. Pennell;Linda M. Abriola - 通讯作者:
Linda M. Abriola
Remediation of groundwater contaminated with perfluoroalkyl acids and chlorinated ethenes using a microbial reductive dechlorination and sorptive material treatment train
使用微生物还原脱氯和吸附材料处理系统修复受全氟烷基酸和氯乙烯污染的地下水
- DOI:
10.1016/j.watres.2025.124009 - 发表时间:
2025-10-01 - 期刊:
- 影响因子:12.400
- 作者:
Peng-Fei Yan;Sheng Dong;Matthew J. Woodcock;John D. Fortner;Kurt D. Pennell;Natalie L. Cápiro - 通讯作者:
Natalie L. Cápiro
Prenatal PFAS exposures and cardiometabolic health in middle childhood in the MIREC cohort
MIREC队列中儿童中期的产前全氟烷基物质暴露与心脏代谢健康
- DOI:
10.1016/j.envres.2025.121330 - 发表时间:
2025-06-01 - 期刊:
- 影响因子:7.700
- 作者:
Alan J. Fossa;Amber M. Hall;George D. Papandonatos;Tye E. Arbuckle;Jillian Ashley-Martin;Michael M. Borghese;Jenny Bruin;Aimin Chen;Mandy Fisher;John E. Krzeczkowski;Bruce P. Lanphear;Amanda J. MacFarlane;Katherine E. Manz;Katherine M. Morrison;Youssef Oulhote;Jana Palaniyandi;Mark R. Palmert;Kurt D. Pennell;Ann M. Vuong;Douglas I. Walker;Joseph M. Braun - 通讯作者:
Joseph M. Braun
Kurt D. Pennell的其他文献
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{{ truncateString('Kurt D. Pennell', 18)}}的其他基金
Analysis of Chronic Exposures to Environmental Toxicants
长期接触环境毒物的分析
- 批准号:
7084038 - 财政年份:2006
- 资助金额:
$ 14.15万 - 项目类别:
Quantitative Metabolomic Analysis of Chronic Exposures to Environmental Toxicants
长期暴露于环境毒物的定量代谢组学分析
- 批准号:
7231056 - 财政年份:2006
- 资助金额:
$ 14.15万 - 项目类别:
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