Clinical Research and Mentoring in Oral Epidemiology

口腔流行病学临床研究和指导

• 批准号: 7476505
• 负责人: KAUMUDI J JOSHIPURA
• 金额: $ 15.34万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7476505
• 关键词: Adherence; Antioxidants; Area; Award; Biological Markers; Blood; Budgets; Cardiovascular Diseases; Cardiovascular system; Chronic Disease; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Complement; Congestive Heart Failure; Dental; Dental Epidemiology; Dental Schools; Dentists; Development; Diabetes Mellitus; Dietary Fiber; End Point; Environment; Epidemiologic Studies; Epidemiology; Ethnic group; Evaluation of Risk Factors; Familiarity; Fluorides; Freedom; Funding; Goals; Grant; Guidelines; Head; Health Policy; Hemostatic Agents; India; Individual; Inflammatory; Institution; Intake; Internal Medicine; Journals; K-Series Research Career Programs; Learning; Letters; Malignant Neoplasms; Manuscripts; Mediating; Mediator of activation protein; Medicine; Mentors; Methods; Mid-Career Clinical Scientist Award (K24); Molecular Epidemiology; Molecular Genetics; Mouth Diseases; New England; Nursing Faculty; Obesity; Oral; Oral health; Pathway interactions; Periodontal Diseases; Physicians; Play; Policies; Pregnancy Outcome; Principal Investigator; Public Health Schools; Publications; Publishing Peer Reviews; Qualifying; Range; Research; Research Design; Research Personnel; Research Project Grants; Research Proposals; Role; Running; Staging; Students; Support of Research; Systemic disease; Time; Tooth Loss; Training; Training Programs; United States National Institutes of Health; Universities; Work; Writing; career; cohort; dental surgery; experience; genetic epidemiology; interest; nutrition; oral condition; patient oriented; patient oriented research; professor; programs; racial and ethnic; research facility; skills

DESCRIPTION (provided by applicant): The principal investigator's career has emphasized patient oriented research in Oral Epidemiology ranging from evaluation of risk factors, to mechanistic studies evaluating pathways, to clinical trials. Her ongoing funded research focuses on the relationships between oral conditions, inflammatory markers, nutrition and specific cardiovascular diseases. She has expanded this work to include additional cardiovascular endpoints and pregnancy outcomes, and is starting to work in diabetes. The principal investigator plans to gain additional research skills by learning Molecular and Genetic Epidemiology, which would substantially enhance her research. The principal investigator co-directs the comprehensive T32 training grant titled "New England Oral Disease Epidemiology Training Program" which is run jointly across the Harvard School of Dental Medicine and Harvard School of Public Health. The K24 award will nicely complement the T32 by providing the protected time to enhance mentoring. The principal investigator has substantial experience in mentoring trainees at different stages including students in the DMD program, clinicians seeking a doctoral degree in Epidemiology, and junior clinical faculty. These activities have resulted in a NIH small grant and a K-award headed by her mentees, and 21 peer reviewed published manuscripts with her mentees. This midcareer investigator award will allow the principal investigator to spend more time in mentoring and retaining clinicians (dentists as well as some physicians) in Oral Epidemiology research, and in helping them to become independent clinical researchers. There is a strong institutional commitment and a growing pool of clinicians seeking training and mentoring in Oral Epidemiology. The K24 will thus provide the much needed protected time and support at a critical time, which will enable her to build a strong research program in oral and systemic disease with an excellent team of patient oriented researchers, whom the principal investigator mentors. Candidate: Dr. Joshipura is an Associate Professor on Oral Health Policy and Epidemiology at the Harvard School of Dental Medicine, and an Associate Professor in Epidemiology at the Harvard School of Public Health. She received a degree in dental surgery from Bombay University, India in 1982, a MS in Biostastics from the Harvard School of Public Health in 1982, and ScD in Epidemiology from the Harvard School of Dental Medicine and Harvard School of Public Health. She has an impressive list of publications in leading journals including JAMA, New England J Med, JNCI, Annals of Internal Medicine as well as the leading dental journals. She has an impressive track record of funded research in the area of chronic diseases, pregnancy outcomes, and periodontal disease. The candidate documented the ability to provide mentoring to beginning clinical investigators by listing 21 students to whom she has provided a mentoring role. Most, but not all, of these mentored individuals where dentists. The types of research have varied widely and include molecular epidemiology, periodontal disease and blood biomarkers, fluoride, cancer, obesity, and other topics. Her long-term career goal is built a research program in oral and systemic disease with a strong team of collaborators and mentees. There are enthusiastic letters of commitment from the Dean of Harvard School of Dental Medicine (Dr. Bruce Donoff) who provides a commitment that she will be able to spend at least 50% on patient-oriented research, a letter from Dr. Douglass who recommends her without qualifications, and Dr. Stampfer who similarly enthusiastically supports Dr. Joshipura and indicates the she plays a major role in the Oral Epidemiology training program. Research Plan: With respect to the currently supported research, Dr. Joshipura provides enough information in the areas of the hypotheses and the specific aims, background, significance and rationale, preliminary studies and results, research designs and methods. Her specific aims are to relate dental status to systemic disease, to determine the extent to which the systemic disease-dental status association is mediated by inflammatory and hemostatic mediators, and by intake of dietary fiber and antioxidants. Different cohorts in which these aims can be assessed are listed and the investigator has extensive familiarity with these cohorts as is exemplified by her publications. She provides as an example of one specific project where the association between periodontal disease and tooth loss was investigated. For this specific project she lists the specific aims, background, significance and rationale, preliminary studies and results, research designs and methods. It appears that no new research to be specifically supported by this grant is listed because Dr. Joshipura feels strongly that mentees should have the freedom to choose their thesis topics as well as additional projects to the extent feasible. Mentors: The availability of beginning clinician investigators for mentoring is described and includes T32 trainees. Individuals from underrepresented racial/ethnic groups will be specifically targeted for recruitment. The types of educational experiences the candidate will provide include selecting of appropriate course work, identification of a research project and a research mentor, guidance with respect to preparing for the written and oral qualifying exams, and make the trainee familiar with administrative policies and adherence to administrative guidelines. Environment and Institutional Commitment: The letters of support indicate a commitment to the scientific development of the candidate, an adequacy of research facilities, a provision of adequate protected time, and a commitment of the institution towards career development. Budget: No concerns

描述（由申请人提供）：主要研究者的职业生涯一直强调以患者为导向的口腔流行病学研究，从风险因素的评估，到机制研究评估途径，再到临床试验。她正在进行的资助研究主要集中在口腔条件，炎症标志物，营养和特定的心血管疾病之间的关系。她已经将这项工作扩展到包括额外的心血管终点和妊娠结局，并开始在糖尿病方面开展工作。首席研究员计划通过学习分子和遗传流行病学来获得额外的研究技能，这将大大提高她的研究。主要研究者共同指导名为“新英格兰口腔疾病流行病学培训计划”的综合T32培训补助金，该计划由哈佛牙科医学院和哈佛公共卫生学院联合开展。K24奖项将很好地补充T32，提供受保护的时间来加强指导。主要研究者在指导不同阶段的学员方面有丰富的经验，包括DMD项目的学生、攻读流行病学博士学位的临床医生和初级临床教师。这些活动导致了NIH的小额赠款和K奖由她的学员领导，和21同行评审发表的手稿与她的学员。这个职业中期研究者奖将允许主要研究者花更多的时间指导和留住口腔流行病学研究的临床医生（牙医以及一些医生），并帮助他们成为独立的临床研究人员。有一个强大的机构承诺和越来越多的临床医生寻求培训和指导口腔流行病学。因此，K24将在关键时刻提供急需的保护时间和支持，这将使她能够在口腔和全身性疾病方面建立一个强大的研究计划，拥有一支优秀的以患者为导向的研究人员团队，主要研究者指导他们。 候选人：Joshipura博士是哈佛牙科医学院口腔健康政策和流行病学副教授，也是哈佛公共卫生学院流行病学副教授。她于1982年获得印度孟买大学牙科手术学位，1982年获得哈佛公共卫生学院生物统计学硕士学位，并获得哈佛牙科医学院和哈佛公共卫生学院流行病学理学博士学位。她在领先的期刊上发表了令人印象深刻的文章，包括JAMA，新英格兰J Med，JNCI，内科年鉴以及领先的牙科期刊。她在慢性病、妊娠结局和牙周病领域的资助研究方面有着令人印象深刻的记录。 候选人通过列出21名她提供指导的学生来记录为开始临床研究者提供指导的能力。大多数，但不是全部，这些指导个人在牙医。研究类型多种多样，包括分子流行病学、牙周病和血液生物标志物、氟化物、癌症、肥胖和其他主题。她的长期职业目标是建立一个口腔和全身性疾病的研究计划，拥有强大的合作者和学员团队。有哈佛口腔医学院院长热情洋溢的承诺书（布鲁斯多诺夫博士）谁提供了一个承诺，她将能够花费至少50%的病人为导向的研究，一封信从道格拉斯博士谁推荐她没有资格，Stampfer博士同样热情地支持Joshipura博士，并表示她在口腔流行病学培训中发挥了重要作用程序. 研究计划：关于目前资助的研究，Joshipura博士提供了足够的信息，包括假设和具体目标，背景，意义和基本原理，初步研究和结果，研究设计和方法。她的具体目标是将牙齿状况与全身性疾病联系起来，以确定全身性疾病-牙齿状况关联在多大程度上是由炎症和止血介质以及膳食纤维和抗氧化剂的摄入介导的。列出了可以评估这些目标的不同队列，研究者对这些队列非常熟悉，如其出版物所示。她提供了一个具体项目的例子，其中牙周病和牙齿脱落之间的关联进行了调查。对于这个具体的项目，她列出了具体的目标，背景，意义和基本原理，初步研究和结果，研究设计和方法。 似乎没有新的研究将特别支持这项补助金被列出，因为博士Joshipura强烈认为，学员应该有自由选择他们的论文题目以及其他项目，在可行的范围内。 导师：介绍了初级临床研究者的可用性，包括T32学员。来自代表性不足的种族/族裔群体的个人将被专门作为招聘对象。候选人将提供的教育经验类型包括选择适当的课程工作，确定研究项目和研究导师，指导准备书面和口头资格考试，并使受训者熟悉行政政策和遵守行政准则。 环境和机构承诺：支持信表明对候选人科学发展的承诺，充足的研究设施，提供足够的保护时间，以及机构对职业发展的承诺。 预算：没有问题